Evidence map›Paper›PMID 35717553›Full record

ArticleImmunologic research2022

Livin promotes Th2-type immune response in airway allergic diseases.

Yue Wang, Zhiyu Xiang, Miaomiao An, Huijing Jia, Chunyan Bu, Yanfeng Xue, Yao Wei, Ruiying Li, Xueping Qi, Fengli Cheng and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunologic research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Yue Wang *Department of Otolaryngology, Head & Neck Surgery, The Second Clinical Medical College, Shanxi Medical University, Taiyuan, China.
Zhiyu Xiang *Department of Otolaryngology, Head & Neck Surgery, The Second Clinical Medical College, Shanxi Medical University, Taiyuan, China.
Miaomiao An *Department of Otolaryngology, Head & Neck Surgery, The Second Clinical Medical College, Shanxi Medical University, Taiyuan, China.
Huijing Jia *Department of Otolaryngology, Head & Neck Surgery, The Second Clinical Medical College, Shanxi Medical University, Taiyuan, China.
Chunyan BuDepartment of Otolaryngology, Head & Neck Surgery, The First Hospital of Yulin, Yulin, China.
Yanfeng XueSpecial Needs Ward, Shanxi Cancer Hospital, Taiyuan, China.
Yao WeiDepartment of Otolaryngology, Head & Neck Surgery, The Second Clinical Medical College, Shanxi Medical University, Taiyuan, China.
Ruiying LiDepartment of Otolaryngology, Head & Neck Surgery, The Second Clinical Medical College, Shanxi Medical University, Taiyuan, China.
Xueping QiDepartment of Otolaryngology, Head & Neck Surgery, The Second Hospital of Shanxi Medical University, Taiyuan, China.
Fengli ChengDepartment of Otolaryngology, Head & Neck Surgery, The Second Hospital of Shanxi Medical University, Taiyuan, China.
Changqing ZhaoDepartment of Otolaryngology, Head & Neck Surgery, The Second Hospital of Shanxi Medical University, Taiyuan, China.
Jinmei XueDepartment of Otolaryngology, Head & Neck Surgery, The Second Hospital of Shanxi Medical University, Taiyuan, China. xjment@126.com.ORCID 0000-0002-7428-7812
Pingchang YangResearch Center of Allergy & Immunology, Shenzhen University School of Medicine, Shenzhen, China. pcy2356@szu.edu.cn.
Shanxi Medical University · CNShanxi Provincial Cancer Hospital · CNShenzhen University · CNYulin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the effects of livin on the Th2 immune response in airway allergic diseases (AAD) and explore the interaction among livin, GATA3, IL-4 in peripheral blood CD4

methodsWT mice and livin KO mice were developed for model of AAD. Th2 cell levels in the lung tissues and spleen were assessed by flow cytometry. Also, it was assessed in the culture after exposing to livin inhibitor (Lp-15); the protein and mRNA levels of livin, GATA3 and IL-4 in peripheral blood CD4

resultsCompared with WT mouse, Th2 cell frequency in lung tissues and spleen was significantly decreased in livin KO mouse; after adding Lp-15, the differentiation from Naive CD4

conclusionLivin increases the expression of IL-4 and facilitates naive CD4

Indexed as

Inhibitor of Apoptosis ProteinsRespiratory HypersensitivityTh2 CellsAnimalsCytokinesDisease Models, AnimalGATA3 Transcription FactorHypersensitivityImmunityInterleukin-4MiceRNA, MessengerCytokinesGATA3 Transcription FactorInhibitor of Apoptosis ProteinsInterleukin-4livin protein, mouseRNA, MessengerAADCD4+ T cellsGATA3LivinTh2 differentiation

Identifiers

PMID35717553
PMCPMC9499890
OpenAlexW4283072274

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.