ArticleBMC pediatrics2022
Serum matrix metalloproteinase-7 levels in infants with cholestasis and biliary atresia.
Article in BMC pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 5 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 5 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Serum predictors of native liver survival post-Kasai: Systematic review and meta-analysis.Journal of pediatric gastroenterology and nutrition · 2026Pooled it
- The diagnostic accuracy of MMP-7 for the diagnosis for biliary atresia- a systematic review and meta-analysis.BMC pediatrics · 2025Pooled it
- Serum matrix metalloproteinase-7 (MMP-7) as a Biomarker for differentiating biliary atresia from neonatal hepatitis: evidence synthesis through systematic review and meta-analysis.Pediatric surgery international · 2025Pooled it
- Effect of serum MMP-7 on the diagnostic accuracy of biliary atresia: systematic review and meta-analysis.Frontiers in pharmacology · 2025Pooled it
- Comparison for the diagnostic performance of early diagnostic methods for biliary atresia: a systematic review and network meta-analysis.Pediatric surgery international · 2024Pooled it
- Non-Invasive Biomarkers for Assessing Liver Fibrosis in Biliary Atresia: A Literature Review.International journal of molecular sciences · 2026Review
- A comprehensive diagnostic model based on serum MMP-7: a convenient and efficient early diagnostic method for biliary atresia.BMC pediatrics · 2026Article
- Measuring MMP-7 levels in dried blood spots appears not feasible for newborn screening of biliary atresia.Hepatology communications · 2026Article
- Development and validation of a minimally invasive diagnostic model for biliary atresia using artificial intelligence.World journal of pediatrics : WJP · 2025Article
- Advances in prognostic biomarkers for biliary atresia: Current insights and future directions.Journal of pediatric gastroenterology and nutrition · 2025Review
- Accurate prediction of biliary atresia with an integrated model using MMP-7 levels and bile acids.World journal of pediatrics : WJP · 2024Article
- Development of a diagnostic model for biliary atresia based on MMP7 and serological tests using machine learning.Pediatric surgery international · 2024Article
- Serum matrix metalloproteinase-7 for discriminating biliary atresia: a diagnostic accuracy and validation study.Journal of translational medicine · 2024Article
- Progress in Biomarkers Related to Biliary Atresia.Journal of clinical and translational hepatology · 2024Review
- Diseases of bile duct in children.World journal of gastroenterology · 2024Review
- The magnetic resonance imaging and age-adjusted matrix metalloproteinase-7 assist the diagnosis of biliary atresia.Journal of gastroenterology · 2024Article
- FIB-4 and APRI scores for progressive liver fibrosis diagnosis in children with biliary atresia.Frontiers in pediatrics · 2023Article
- Questioning Diagnostic Value of Serum Matrix Metalloproteinase 7 for Biliary Atresia.Journal of clinical and experimental hepatologyArticle
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to evaluate the serum level of matrix metalloproteinase 7 (MMP7) in infants with cholestasis and the diagnostic values of this biomarker to differentiate biliary atresia (BA) from other causes of cholestasis.
methodsThis multi-center study is conducted during 2 years in Mofid children's hospital and Children's Medical Center, Pediatrics Center of Excellence Tehran, Iran. 54 infants with cholestasis were enrolled in this study with a control group consists of 41 healthy infants with the same age. Serum samples were taken from all these patients to assess serum levels of MMP7, Gamma-glutamyl Transferase (GGT). For each biomarker, we calculated the sensitivity and specificity and other statistical characteristics.
resultsThere were 89 subjects, 22 patients with BA, 32 patients with non-BA cholestasis and 41 subjects as control group. The mean serum MMP7 levels in BA, non-BA cholestasis and control group was 15.91 ng/ml ± 6.64, 4.73 ng/ml ± 2.59 and 0.49 ng/ml ± 0.33, respectively. The best cut-off point is calculated 7.8 ng/ml for MMP7 and 434.5 U/L for GGT. The area under curve (AUC) for these two markers are 0.988 ± 0.008 and 0.854 ± 0.052, respectively. The sensitivity and specificity of MMP7 to differentiate biliary atresia from nonbiliary atresia cholestasis in our study was 95.5% and 94.5%, respectively. The sensitivity and specificity of GGT was 77.3% and 77.8%, respectively. These results show that the MMP7 has more sensitivity and specificity in differentiation.
conclusionMMP7 demonstrated good accuracy to differentiate biliary atresia from other causes of cholestasis.
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