ArticleUrology2022
Delineating the Role of the Urinary Metabolome in the Lithogenesis of Calcium-Based Kidney Stones.
Article in Urology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 8 citations in OpenAlex.
- Serum and urine metabolomic profiling in Miniature Schnauzer dogs with and without calcium oxalate urolithiasis.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Gut microbiome and metabolome signatures in calcium oxalate stone recurrence: a multi-omics study.Microbial cell factories · 2026Article
- Microbiota and kidney disease: the road ahead.Nature reviews. Nephrology · 2025Review
- Mechanism of Nephrolithiasis: Does the Microbiome Play a Role?European urology focus · 2024Review
- Mendelian randomization study of urolithiasis: exploration of risk factors using human blood metabolites.BMC urology · 2024Article
- Article
- Short-term effects of ambient air pollution on emergency department visits for urolithiasis: A time-series study in Wuhan, China.Frontiers in public health · 2023Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveTo delineate the role of the urinary metabolome in the genesis of urinary stone disease (USD).
methodsUntargeted metabolomics was utilized in comparative analyses of calcium-based stones (CBS) and spot urine samples from patients with a history of USD with or without urinary stone activity based on radiologic imaging. Stone and urine metabolomes were stratified by composition and radiographic stone-activity, respectively. Additionally, we quantified highly abundant metabolites that were present in either calcium oxalate (CaOx) or calcium phosphate (CaPhos) stones and also significantly enriched in the urine of active stone formers (SF) compared to non-active SF. These data were used to delineate either a direct involvement of urinary metabolites in lithogenesis or the passive uptake of biomolecules within the stone matrix.
resultsUrinary metabolomes were distinct based on radiographic stone-activity and the 2 types of CBS. Stratification by radiologic stone activity was driven by the enrichment of 14 metabolites in the urine of active SF that were also highly abundant in both CaOx and CaPhos stones, indicative of a potential involvement of these metabolites in lithogenesis. Using the combination of these 14 metabolites in total, we generated a model that correctly classified patients as either active vs non-active SF in a prospectively recruited cohort with 73% success.
conclusionCollectively, our data suggest specific urinary metabolites directly contribute to the formation of urinary stones and that active SF may excrete higher levels of lithogenic metabolites than non-active patients. Future studies are needed to confirm these findings and establish the causative mechanisms associated with these metabolites.
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