SynthesisGastroenterology2022
Risk Factors for Abdominal Pain-Related Disorders of Gut-Brain Interaction in Adults and Children: A Systematic Review.
Synthesis in Gastroenterology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07000227 (Mechanism of FODMAP Restriction on Gut Microbiota and Gut Barrier Function in Functional Gastrointestinal Disorder Patients), which is not on this map. Cited by 73 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Mechanism of FODMAP Restriction on Gut Microbiota and Gut Barrier Function in Functional Gastrointestinal Disorder Patients : A Randomised Controlled Trial
Who cites it
73 citing papers in PubMed, 2 syntheses or guidelines pooled it, 118 citations in OpenAlex.
- Global Prevalence of Functional Abdominal Pain Disorder among Children and Adolescents According to the Rome III and IV Criteria: A Systematic Review and Meta-Analysis.Gut and liver · 2026Pooled it
- Positive psychological well-being and clinical characteristics in IBS: A systematic review.General hospital psychiatryPooled it
- The Role of Psychosocial Risk Status in Relation to Outcomes Following Cognitive Behavioral Therapy for Youth with Abdominal Pain-Related Disorders of Gut-Brain Interaction.Journal of clinical psychology in medical settings · 2026Trial
- A Randomized Waitlist-Controlled Trial of a Positive Psychology Intervention for Irritable Bowel Syndrome: The WISH Proof-of-Concept Trial.Neurogastroenterology and motility · 2025Trial
- Dietary Modifications in IBS Leads to Reduced Symptoms, Weight, and Lipid Levels: Two Randomized Clinical Trials.Nutrients · 2025Trial
- A Starch- and Sucrose-Reduced Diet Has Similar Efficiency as Low FODMAP in IBS-A Randomized Non-Inferiority Study.Nutrients · 2024Trial
- Irritable bowel syndrome.Nature reviews. Disease primers · 2026Review
- Suppression of visceral nociception by C-fiber transmission block using temporal interference sinusoidal stimulation.Pain reports · 2026Article
- Associations between childhood behavior and current cognitive and emotional function in adults with irritable bowel syndrome-a cross sectional retrospective study.BMC gastroenterology · 2026Observational
- Enteric and Sympathetic Nervous System Pathways Mediate Early Life Stress Effects on Gut Motility and Pain: Mechanistic Findings With Human Correlation.Gastroenterology · 2026Article
- Incidental Epiploic Appendagitis With Contralateral Anterior Cutaneous Nerve Entrapment Syndrome in an Adolescent.ACG case reports journal · 2026Article
- IBS stress reactivity phenotype is associated with blood transcriptome profiles and microstructural and functional brain changes.Neurobiology of stress · 2026Article
- Felt Stigma in Youth With Disorders of Gut-Brain Interaction: Implications for Abdominal Pain, Sleep, and Mood.Clinical pediatrics · 2026Article
- Fundamentals of Neurogastroenterology: Basic Science.Gastroenterology · 2026Review
- Article
- Psychological Traits and Social Factors Associated with Irritable Bowel Syndrome in Children.Children (Basel, Switzerland) · 2026Article
- Postsurgical Disorders of the Gut-Brain Axis and the Need for Multidisciplinary Treatment Approach: Authors' Reply.Neurogastroenterology and motility · 2026Article
- Exploring Associations of Different Types of Childhood Trauma With Symptomatology in Irritable Bowel Syndrome.Neurogastroenterology and motility · 2026Article
- Adult Rome IV Disorders of Gut-Brain Interaction in a Pediatric Population.Children (Basel, Switzerland) · 2026Article
- A Roadmap for Advancing Women's Health in Disorders of the Gut-Brain Interaction.United European gastroenterology journal · 2026Review
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
Abstract
BACKGROUND &
aimsMany studies have assessed risk factors of irritable bowel syndrome (IBS) and other abdominal pain-related disorders of gut-brain interaction (AP-DGBI); however, the role of these factors is unclear due to heterogeneous study designs. The aim of this systematic review was to extensively evaluate the literature and determine clinical risk and protective factors for the presence and persistence of AP-DGBI in children and adults.
methodsA PubMed search identified studies investigating potential risk and protective factors for AP-DGBI in adults and children. Inclusion criteria included fully published studies with a control group; exclusion criteria included poor-quality studies (using a validated scale). For each factor, the proportion of studies that found the factor to be a risk factor, protective factor, or neither was summarized. The number of studies, diagnostic criteria, number of subjects, and average study quality rating provided further context. Whenever possible, a meta-analysis generated pooled odds ratios or mean difference.
resultsThe systematic review included 348 studies. Female sex, gastroenteritis, abuse, stress, psychological disorders, somatic symptoms, and poor sleep were consistent risk factors for developing AP-DGBI in adults and children. In adults, additional risk factors included obesity, smoking, and increased use of medical resources. Protective AP-DGBI factors in adults included social support and optimism; no studies for protective factors were found for children.
conclusionsThere are multiple risk factors for AP-DGBI in adults and children. These include female sex, gastroenteritis, abuse, stress, poor sleep, obesity, psychological disorders, and somatic symptoms. Additional studies are needed in children, on protective factors, and on factors associated with persistence of AP-DGBI.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.