Evidence map›Paper›PMID 35716586›Full record

ArticleBioorganic & medicinal chemistry2022

Discovery of agonist-antagonist pairs for the modulation of Ca

Alexandria V Slayden, Christy L Dyer, Dejian Ma, Wei Li, Anna N Bukiya, Abby L Parrill, Alex M Dopico

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Alexandria V SlaydenDepartment of Pharmacology, Addiction Science and Toxicology, College of Medicine, The University of Tennessee Health Science Center, Memphis TN, 38103, USA.
Christy L DyerDepartment of Chemistry, The University of Memphis, Memphis TN, 38152, USA.
Dejian MaDepartment of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee Health Science Center, Memphis TN, 38163, USA.
Wei LiDepartment of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee Health Science Center, Memphis TN, 38163, USA.
Anna N BukiyaDepartment of Pharmacology, Addiction Science and Toxicology, College of Medicine, The University of Tennessee Health Science Center, Memphis TN, 38103, USA.
Abby L ParrillDepartment of Chemistry, The University of Memphis, Memphis TN, 38152, USA.
Alex M DopicoDepartment of Pharmacology, Addiction Science and Toxicology, College of Medicine, The University of Tennessee Health Science Center, Memphis TN, 38103, USA. Electronic address: adopico@uthsc.edu.
University of Tennessee Health Science Center · USUniversity of Memphis · US

Funding

ETHANOL ACTIONS ON SLO CHANNELS FROM ARTERIES VS BRAINR01AA011560 · NIAAA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI Alex Dopico · 2001 to 2026
$4.4M
Ethanol actions on slo channels from arteries vs. brainR37AA011560 · NIAAA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI DOPICO, ALEX M. · 2009 to 2018
$3.6M
Regulation of arterial diameter through specific sensing of endogenous steroids and novel nonsteroidal analogs by BK channel subunitsR01HL147315 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI DOPICO, ALEX M. · 2019 to 2022
$2.4M
Acquisition of a Q-TOF Mass SpectrometerS10OD010678 · OD · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI LI, WEI · 2012 to 2012
$325k
NHLBI NIH HHS R01 HL147315NIAAA NIH HHS R01 AA011560NIAAA NIH HHS R37 AA011560NIH HHS S10 OD010678
6 · The paper itself

Abstract

Large conductance, calcium/voltage-gated potassium channels (BK) regulate critical body processes, including neuronal, secretory and smooth muscle (SM) function. While BK-forming alpha subunits are ubiquitous, accessory beta1 subunits are highly expressed in SM. This makes beta1 an attractive target for pharmaceutical development to treat SM disorders, such as hypertension or cerebrovascular spasm. Compounds activating BK via beta1 have been identified, yet they exhibit low potency and off-target effects while antagonists that limit agonist activity via beta 1 remain unexplored. Beta1-dependent BK ligand-based pharmacophore modeling and ZINC database searches identified 15 commercially available hits. Concentration-response curves on BK alpha + beta1 subunit-mediated currents were obtained in CHO cells. One potent (EC

Indexed as

CalciumLarge-Conductance Calcium-Activated Potassium Channel beta SubunitsAnimalsCricetinaeCricetulusLarge-Conductance Calcium-Activated Potassium ChannelsPatch-Clamp TechniquesCalciumLarge-Conductance Calcium-Activated Potassium Channel beta SubunitsLarge-Conductance Calcium-Activated Potassium ChannelsAutomated patch-clampBeta1 subunitDrug designMaxiK channelStructure-activity relationship

Identifiers

PMID35716586
PMCPMC10464842
OpenAlexW4282578032

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.