ArticleHearing research2022
Age-related stereocilia pathology in the human cochlea.
Article in Hearing research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Discovering Age- and Sex-Specific Genetic Risk Factors in Sensorineural Hearing Loss: Genome-Wide Evidence from Large-Scale Biobanks.Journal of the Association for Research in Otolaryngology : JARO · 2026Pooled it
- Comparing physiological signatures of synaptopathic noise exposure and carboplatin-induced inner-hair-cell dysfunction in chinchillas.Hearing research · 2026Article
- Differentiating the Physiological Signatures of Cochlear Synaptopathy and Inner Hair Cell Damage in a Chinchilla Model.bioRxiv : the preprint server for biology · 2026Article
- Early Signs of Aging in Auditory Function Reflected in the Event-Related Potentials.Journal of the American Academy of Audiology · 2026Article
- Hair cell loss - cause or consequence of hearing loss?Frontiers in cell and developmental biology · 2026Review
- Chronic suppurative otitis media: disrupted host-microbial interactions and immune dysregulation.Frontiers in immunology · 2025Review
- Histopathological change of age-related hearing loss in female advance-aged CBA/CaJ mice.PloS one · 2025Article
- From genomic discovery to application in age-related hearing loss: a global bibliometric and cross-ethnic analysis.Frontiers in aging neuroscience · 2025Article
- The perception of emotion in music by people with hearing loss and people with cochlear implants.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Delayed hearing loss after cochlear implantation: Re-evaluating the role of hair cell degeneration.Hearing research · 2024Article
- Neural Adaptation at Stimulus Onset and Speed of Neural Processing as Critical Contributors to Speech Comprehension Independent of Hearing Threshold or Age.Journal of clinical medicine · 2024Article
- Large-scale annotated dataset for cochlear hair cell detection and classification.Scientific data · 2024Article
- Predicting Atrophy of the Cochlear Stria Vascularis from the Shape of the Threshold Audiogram.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Large-scale annotated dataset for cochlear hair cell detection and classification.bioRxiv : the preprint server for biology · 2023Article
- Influence of tinnitus, lifetime noise exposure, and firearm use on hearing thresholds, distortion product otoacoustic emissions, and their relative metric.The Journal of the Acoustical Society of America · 2023Article
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- The hair cell analysis toolbox is a precise and fully automated pipeline for whole cochlea hair cell quantification.PLoS biology · 2023Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Age-related hearing loss in humans is characterized by progressive loss of threshold sensitivity, especially at high frequencies. A multivariable regression of histopathological metrics from normal-aging human cochleae (Wu et al., 2020) showed that hair cell loss better predicts the audiometric shifts than either neural loss or strial atrophy, however considerable variability in age-related threshold elevation remained unexplained. Here, we develop and apply an algorithm to quantify stereocilia pathology in high-power confocal images of inner and outer hair cells in normal aging human cochleae, aged 21 - 71 yrs. Microdissected epithelial wholemounts of the cochleae were immunostained for myosin VIIa and espin to show cuticular plates and stereocilia, respectively, and each cochlea was imaged at 10 log-spaced locations along the cochlear spiral. An approach based on Fourier transforms was used to quantify the regularity of each stereocilia bundle, and the outcome was compared to a parallel analysis by a human observer. Results show a significant age-related decline in stereocilia regularity and increase in stereocilia loss and fusion. Stereocilia pathology was especially severe on the outer hair cells and in the basal half of the cochlea, and may represent a key contributor to age-related threshold elevations. For the one case with an associated pre-mortem audiogram, the threshold shifts are better predicted from the pattern of stereocilia damage than from the pattern of hair cell loss alone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.