Evidence map›Paper›PMID 35715996›Full record

ArticleJournal of medical radiation sciences2022

Correcting rotational error in rectal cancer radiation therapy: Can planning target volume margins be safely reduced?

Vivian Seah, Kylie Dundas, Felicity Hudson, Yolanda Surjan, Rebecca Bartlett, Rebecca Ko, Sandie Smith, Sankar Arumugam, Meredith Johnston, Karen Wong and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical radiation sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Setup and target volume shape variation in rectal cancer radiotherapy: a systematic literature review.Technical innovations & patient support in radiation oncology · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Vivian SeahMedical Radiation Science (Radiation Therapy), School of Health Sciences, University of Newcastle, Callaghan, New South Wales, Australia.ORCID https://orcid.org/0000-0002-9568-6767
Kylie DundasLiverpool and Macarthur Cancer Therapy Centres, Liverpool, New South Wales, Australia.
Felicity HudsonLiverpool and Macarthur Cancer Therapy Centres, Liverpool, New South Wales, Australia.
Yolanda SurjanMedical Radiation Science (Radiation Therapy), School of Health Sciences, University of Newcastle, Callaghan, New South Wales, Australia.
Rebecca BartlettLiverpool and Macarthur Cancer Therapy Centres, Liverpool, New South Wales, Australia.
Rebecca KoLiverpool and Macarthur Cancer Therapy Centres, Liverpool, New South Wales, Australia.
Sandie SmithLiverpool and Macarthur Cancer Therapy Centres, Liverpool, New South Wales, Australia.
Sankar ArumugamLiverpool and Macarthur Cancer Therapy Centres, Liverpool, New South Wales, Australia.
Meredith JohnstonLiverpool and Macarthur Cancer Therapy Centres, Liverpool, New South Wales, Australia.
Karen WongLiverpool and Macarthur Cancer Therapy Centres, Liverpool, New South Wales, Australia.
Mark LeeLiverpool and Macarthur Cancer Therapy Centres, Liverpool, New South Wales, Australia.

Funding

South Western Sydney Local Health District
6 · The paper itself

Abstract

introductionThe magnitude and impact of rotational error is unclear in rectal cancer radiation therapy. This study evaluates rotational errors in rectal cancer patients, and investigates the feasibility of planning target volume (PTV) margin reduction to decrease organs at risk (OAR) irradiation.

methodsIn this study, 10 patients with rectal cancer were retrospectively selected. Rotational errors were assessed through image registration of daily cone beam computed tomography (CBCT) and planning CT scans. Two reference treatment plans (TP

resultsMean rotational errors in pitch, roll and yaw were -0.72 ± 1.81°, -0.04 ± 1.36° and 0.38 ± 0.96° respectively. Pitch resulted in the largest potential circumferential displacement of clinical target volume (CTV) at 1.42 ± 1.06 mm. Pre-determined rotational errors resulted in statistically significant differences in CTV, small bowel, femoral heads and iliac crests (P < 0.05). Only small bowel and iliac crests failed clinical compliance, with majority in the PTV 10 mm margin group.

conclusionRotational errors affected clinical compliance for OAR dose but exerted minimal impact on CTV coverage even with reduced PTV margins. Both PTV margin reduction and rotational correction decreased irradiated volume of OAR. PTV margin reduction to 5 mm is feasible, and rotational corrections are recommended in rectal patients to further minimise OAR irradiation.

Indexed as

Radiotherapy, Intensity-ModulatedRectal NeoplasmsHumansOrgans at RiskRadiotherapy DosageRadiotherapy Planning, Computer-AssistedRetrospective Studiesclinical site, image guided radiation therapy (IGRT)discipline, gastro intestinalradiation therapyradiation therapy, intensity modulated radiation therapy (IMRT)radiation therapy, marginsradiation therapy, organs at risk (OAR)radiation therapy, volumetric modulated arc therapy (VMAT)radiotherapy (Radiation Therapy)

Identifiers

PMID35715996
PMCPMC9714490

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.