ArticleThoracic cancer2022
Prognostic value of systemic inflammatory markers and the nutrition status in thymic epithelial tumors with complete resection.
Article in Thoracic cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinical utility of the pan-immune-inflammation value in breast cancer patients.Frontiers in oncology · 2023Pooled it
- Inflammatory Indices Related to the Postoperative Prognosis of Thymic Epithelial Neoplasms: A Propensity Score Matching Evaluation.Annals of surgical oncology · 2026Article
- An interpretable machine learning approach using nnU-Net-based radiomics for preoperative risk stratification of thymic epithelial tumors: a multicenter study.BMC medical imaging · 2026Article
- Prognostic and predictive biomarkers in thymic epithelial tumors: beyond traditional staging: a narrative review.Mediastinum (Hong Kong, China) · 2026Review
- Narrative review of the prognostic significance of primary tumor size in thymic epithelial tumor.Mediastinum (Hong Kong, China) · 2025Review
- Development and approval of a Lasso score based on nutritional and inflammatory parameters to predict prognosis in patients with glioma.Frontiers in oncology · 2025Article
- Prognostic value of systemic inflammatory markers and the nutrition status in thymic epithelial tumors with complete resection.Thoracic cancer · 2022Article
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7 authors.
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Abstract
backgroundRecent studies have shown that several systemic inflammatory markers and the nutrition status, including the neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), and prognostic nutritional index (PNI), are useful prognostic factors in several malignant tumors. The present study explored the prognostic value of the NLR, MLR, PLR, and PNI in thymic epithelial tumor (TET) patients who underwent complete resection.
methodsA total of 158 TET patients who underwent complete resection were involved in the analysis. Their NLR, MLR, PLR, and PNI values were obtained from a blood examination within one month before the initiation of treatment. A receiver operating characteristic curve analysis was conducted to determine the optimal cutoff values.
resultsThe enrolled patients were stratified by cutoffs of 4.35 for the NLR, 0.22 for the MLR, 130.18 for the PLR, and 44.02 for the PNI. A univariate analysis revealed that high-grade malignant TET, including type B2 and B3 thymoma, thymic carcinoma, and thymic neuroendocrine tumor; an advanced Masaoka stage; a high NLR; a high MLR; and a low PNI were significant predictors of a poor disease-free survival (DFS). A multivariate analysis confirmed that an advanced Masaoka stage (HR = 5.5557, p = 0.0007) and a high MLR (HR = 3.3371, p = 0.0264) were independent predictors of a poor DFS.
conclusionsOur study demonstrated that the pretreatment MLR was an independent predictor of the DFS in patients with TETs who underwent complete resection.
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