ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2022
DNA Methylation "GrimAge" Acceleration Mediates Sex/Gender Differences in Verbal Memory and Processing Speed: Findings From the Health and Retirement Study.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Processing Speed Impairment in Schizophrenia: An Updated Systematic Review and Meta-Analysis.JAMA psychiatry · 2026Pooled it
- Development and validation of MethylCog, a blood DNA methylation proxy for cognition.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Association of Epigenetic Age Acceleration and Mitochondrial DNA-Based Aging Metrics Provides Insights Into Mechanisms of Aging-Related Diseases.Aging cell · 2025Article
- Epigenetic age acceleration and midlife cognition: joint evidence from observational study and Mendelian randomization.npj aging · 2025Article
- How much can biomarkers explain sociodemographic inequalities in cognitive dysfunction and cognitive impairment? Results from a machine learning model in the Health and Retirement Study.Journal of Alzheimer's disease : JAD · 2025Article
- The Interplay Between Biological Aging and Volunteering Engagement in Predicting Cognitive Performance: Evidence From the Harmonized Cognitive Assessment Protocol Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Review
- Methylation and algorithms in biological aging: a scoping review.Frontiers in aging · 2025Review
- Article
- Article
- Diet, Pace of Biological Aging, and Risk of Dementia in the Framingham Heart Study.Annals of neurology · 2024Article
- Epigenetic Age Acceleration and Chronological Age: Associations With Cognitive Performance in Daily Life.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Geroscience and pathology: a new frontier in understanding age-related diseases.Pathology oncology research : POR · 2024Review
- Epigenetics of the far northern Yakutian population.Clinical epigenetics · 2023Article
- Physical activity is associated with slower epigenetic ageing-Findings from the Rhineland study.Aging cell · 2023Article
- Diet, pace of biological aging, and risk of dementia in the Framingham Heart Study.medRxiv : the preprint server for health sciences · 2023Article
- Female APOE ɛ4 Carriers with Slow Rates of Biological Aging Have Better Memory Performances Compared to Female ɛ4 Carriers with Accelerated Aging.Journal of Alzheimer's disease : JAD · 2023Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Whether sex/gender differences in rates of biological aging mediate sex/gender differences in cognition in older adults has not been fully examined. The aim of the current study was to investigate this association. Data from up to 1 928 participants (mean age = 75, standard deviation = 7.04, female = 57%) who took part in the 2016 Harmonized Cognitive Assessment Protocol and Venous Blood Study; substudies of the Health and Retirement Study were included in the current study. The residuals from 4 age-adjusted epigenetic clocks (Horvath, Hannum, PhenoAge, and GrimAge) were used to measure biological age acceleration. Sex/gender differences in cognition were tested using a series of analyses of covariance. Mediation analyses tested whether the measures of age acceleration accounted for these sex/gender differences, controlling for age, education, smoking status, and white blood cell count. Women outperformed men on measures of verbal learning, verbal memory, visual scanning, and processing speed. No other significant sex/gender differences were identified. Results from mediation analyses revealed that women's slower rates of GrimAge fully accounted for their faster processing speeds and partially accounted for their better performances on verbal learning, verbal memory, and visual scanning measures. None of the other measures of age acceleration were significant mediators. Accounting for sex/gender differences in biological aging may differentiate between cognitive sex/gender differences that are driven by universal (ie, age-related) versus sex-specific mechanisms. More broadly, these findings support the growing evidence that the GrimAge clock outperforms other clocks in predicting cognitive outcomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.