ArticleJournal of translational medicine2022
Transdermal deferoxamine administration improves excisional wound healing in chronically irradiated murine skin.
Article in Journal of translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 43 citations in OpenAlex.
- Chronic Radiation-Induced Wounds: Pathogenesis, Current Therapeutic Strategies, and Emerging Regenerative Approaches.International journal of molecular sciences · 2026Review
- Optimization of fat grafting to attenuate radiation damage: a narrative review.Gland surgery · 2026Review
- Deferoxamine Improves Radiation-Induced Peripheral Neuropathy.Journal of cellular and molecular medicine · 2026Article
- Radiotherapy-Induced Skin Fibrosis: Pathophysiology, Emerging Therapeutics, and the Role of Dermatology.American journal of clinical dermatology · 2026Review
- Divergent effects of topical deferoxamine treatment on skin and cancer cells uncovers its potential as a safe radioprotective agent in oncological applications.Cancer cell international · 2026Article
- Mosaic partial epidermal reprogramming remodels neighbors and niches to refine skin homeostasis and repair.Nature communications · 2026Article
- Short-term pretreatment with deferoxamine enhances the in vivo vascularization capacity of nanofat seeded onto dermal substitutes.EXCLI journal · 2026Article
- Multifunctional copper-based metal-organic frameworks/chitosan derivative/exosome composite sponge for skin healing.iScience · 2025Article
- Exploring the potential of repurposed deferoxamine: bridging challenges and novel formulation opportunities.Nanomedicine (London, England) · 2025Review
- Injectable deferoxamine-loaded microsphere hydrogels for inhibition of ferroptosis and promotion of third-degree burn wound healing.Materials today. Bio · 2025Article
- Improving Fat Graft Survival Using Soluble Molecule Preconditioning.Biomolecules · 2025Review
- Cell death and iron deposition in the liver in two murine models of acute radiation syndrome.PloS one · 2025Article
- Hematoxylin and Eosin Architecture Uncovers Clinically Divergent Niches in Pancreatic Cancer.Tissue engineering. Part A · 2024Article
- Hydrogel Microneedle Patches Loaded with Stem Cell Mitochondria-Enriched Microvesicles Boost the Chronic Wound Healing.ACS nano · 2024Article
- Advancements in employing two-dimensional nanomaterials for enhancing skin wound healing: a review of current practice.Journal of nanobiotechnology · 2024Review
- Role of ferroptosis in radiation-induced soft tissue injury.Cell death discovery · 2024Review
- Single-cell transcriptional analysis of irradiated skin reveals changes in fibroblast subpopulations and variability in caveolin expression.Radiation oncology (London, England) · 2024Article
- Adipose-Derived Stromal Cell-Based Therapies for Radiation-Induced Fibrosis.Advances in wound care · 2024Review
- Deferoxamine topical cream superior to patch in rescuing radiation-induced fibrosis of unwounded and wounded skin.Journal of cellular and molecular medicine · 2024Article
- Understanding wound healing in obesity.World journal of experimental medicine · 2024Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundRadiation-induced skin injury is a well-known risk factor for impaired wound healing. Over time, the deleterious effects of radiation on skin produce a fibrotic, hypovascular dermis poorly suited to wound healing. Despite increasing understanding of the underlying pathophysiology, therapeutic options remain elusive. Deferoxamine (DFO), an iron-chelating drug, has been shown in prior murine studies to ameliorate radiation-induced skin injury as well as improve wound healing outcomes in various pathologic conditions when administered transdermally. In this preclinical study, we evaluated the effects of deferoxamine on wound healing outcomes in chronically irradiated murine skin.
methodsWild-type mice received 30 Gy of irradiation to their dorsal skin and were left to develop chronic fibrosis. Stented excisional wounds were created on their dorsal skin. Wound healing outcomes were compared across 4 experimental conditions: DFO patch treatment, vehicle-only patch treatment, untreated irradiated wound, and untreated nonirradiated wounds. Gross closure rate, wound perfusion, scar elasticity, histology, and nitric oxide assays were compared across the conditions.
resultsRelative to vehicle and untreated irradiated wounds, DFO accelerated wound closure and reduced the frequency of healing failure in irradiated wounds. DFO augmented wound perfusion throughout healing and upregulated angiogenesis to levels observed in nonirradiated wounds. Histology revealed DFO increased wound thickness, collagen density, and improved collagen fiber organization to more closely resemble nonirradiated wounds, likely contributing to the observed improved scar elasticity. Lastly, DFO upregulated inducible nitric oxide synthase and increased nitric oxide production in early healing wounds.
conclusionDeferoxamine treatment presents a potential therapeutic avenue through which to target impaired wound healing in patients following radiotherapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.