Evidence map›Paper›PMID 35715747›Full record

ArticleBMC cardiovascular disorders2022

Length of stay and cost of care associated with admissions for atrial fibrillation among patients with cancer.

Avirup Guha, Anubhav Jain, Ankita Aggarwal, Amit K Dey, Sourbha Dani, Sarju Ganatra, Francis E Marchlinski, Daniel Addison, Michael G Fradley

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cardiovascular disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Avirup GuhaHarrington Heart and Vascular Institute, Case Western Reserve University, Cleveland, OH, USA.
Anubhav JainDepartment of Internal Medicine, Wayne State University School of Medicine, Ascension Providence Rochester Hospital, Rochester, MI, USA.
Ankita AggarwalDepartment of Internal Medicine, Wayne State University School of Medicine, Ascension Providence Rochester Hospital, Rochester, MI, USA.
Amit K DeyNational Heart, Lung and Blood Institute, Bethesda, MD, USA.
Sourbha DaniCardio-Oncology Program, Division of Cardiovascular Medicine, Department of Medicine Landsman Heart and Vascular Center, Lahey Hospital and Medical Center, Burlington, MA, USA.
Sarju GanatraCardio-Oncology Program, Division of Cardiovascular Medicine, Department of Medicine Landsman Heart and Vascular Center, Lahey Hospital and Medical Center, Burlington, MA, USA.
Francis E MarchlinskiSection of Cardiac Electrophysiology, Division of Cardiovascular Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Daniel AddisonCardio-Oncology Program, Division of Cardiology, The Ohio State University Medical Center, Columbus, OH, USA.
Michael G FradleySection of Cardiac Electrophysiology, Division of Cardiovascular Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Michael.Fradley@pennmedicine.upenn.edu.ORCID 0000-0001-8352-8975

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Jennifer A. Woyach · 1985 to 2026
$132.3M
Translational Training Grant in Experimental TherapeuticsK12CA133250 · NCI · OHIO STATE UNIVERSITY · PI WILLIAM E. CARSON, Rosa Lapalombella · 2008 to 2026
$15.0M
Early Detection and Mechanisms of Cancer Immunotherapy Associated CardiotoxicityK23HL155890 · NHLBI · OHIO STATE UNIVERSITY · PI ADDISON, DANIEL · 2021 to 2024
$663k
NCI NIH HHS K12 CA133250NCI NIH HHS P30 CA016058NHLBI NIH HHS K23 HL155890
6 · The paper itself

Abstract

backgroundThe aim of this study is to assess the burden of AF-related hospitalizations inclusive of inflation-adjusted cost-of-care and length-of-stay (LOS) among cancer patients and the impact of direct current cardioversion (DCCV) on these outcomes.

methodsUsing the National Inpatient Sample (NIS), patients hospitalized with either a primary or secondary diagnosis of AF and comorbid cancer were identified and both cost of hospitalization and LOS were evaluated for each group. Subgroup analyses were performed for specific cancer types (breast, lung, colon, prostate and lymphoma), and those receiving DCCV.

resultsThe prevalence of co-morbid AF was 8.2 million (16%) and 35.5 million (10%) among those with vs. those without cancer, respectively (odds ratio = 1.6, 95% confidence interval = 1.5-1.7; P < 0.001). Over time, both primary and prevalent AF admissions among those with comorbid cancer increased from 1.1% and 12.3% in 2003 to 1.5% and 21% in 2015, respectively. The total cost of hospitalization increased 94.4% among those with AF and comorbid cancer compared to 23.9% among those without cancer. Among the subgroup of patients with comorbid cancer and primary admission for AF undergoing DCCV, length of stay (2.7 vs. 2.2 days; P < 0.001, model 1) and cost of care ($7,093 vs. 6,152; P < 0.001) were both significantly higher.

conclusionsAF related admissions are increasing for all populations especially amongst those patients with a comorbid diagnosis of cancer, including all cancer subtypes evaluated. Among those patients who underwent DCCV, cancer patients had longer length of stay and increased health care costs.

Indexed as

Atrial FibrillationNeoplasmsElectric CountershockHospitalizationHumansLength of StayMaleRetrospective StudiesAtrial fibrillationCancerCardio-oncologyCardioversion

Identifiers

PMID35715747
PMCPMC9205123

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.