ArticleBMC cardiovascular disorders2022
Predictive value of LDL/HDL ratio in coronary atherosclerotic heart disease.
Article in BMC cardiovascular disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.
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Who cites it
58 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.
- Association of LDL-C/HDL-C ratio with coronary heart disease: A meta-analysis.Indian heart journalPooled it
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- Refined obesity, smoking exposure, and lipid metrics in mortality risk assessment: a nationwide cohort analysis.PloS one · 2026Article
- The ratio of LDL-C to HDL-C can effectively predict the prognosis of IgA nephropathy.Frontiers in medicine · 2026Article
- Metabolic and Weight Observations in Four Women Using Triphasic Norgestimate/Ethinylestradiol: A Six-month Descriptive Case Series.Open access journal of contraception · 2026Article
- Development of a CHD risk prediction model using novel lipid markers based on lipidomics and VAP technology.Frontiers in medicine · 2026Article
- Metoprolol-spironolactone combination for coronary heart disease with concurrent heart failure: impact on cardiac function.American journal of translational research · 2026Article
- Correlation between serum low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio and clinical characteristics of patients with coronary heart disease: a cross-sectional study.Journal of thoracic disease · 2025Article
- Effects of Physical Exercise on Cardiorespiratory Fitness and Cardiometabolic Outcomes in Schizophrenia Spectrum Disorders: The FitForLife National Intervention in Sweden.Life (Basel, Switzerland) · 2025Article
- HDL-C/LDL-C Ratio and All-Cause Mortality in Populations at High CVD Risk: A Prospective Observational Cohort Study.Chronic diseases and translational medicine · 2025Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDyslipidemia is one of independent risk factors for coronary atherosclerotic heart disease (CAHD). We determined whether the LDL/HDL ratio is better than LDL-C or HDL-C alone in predicting the severity of CAHD.
methodsWe performed a retrospective study of 1351 patients with myocardial ischemia who underwent coronary angiography between January 2018 and December 2019 in Shanghai Ninth People's Hospital. Spearman correlation analysis, logistic regression model, Cox proportional hazards model and multicollinearity were used to evaluate LDL/HDL ratio for predicting CAHD severity compared to LDL-C or HDL-C alone.
resultsHigher LDL/HDL ratio was seen in CAHD patients than controls (2.94 ± 1.06 vs 2.36 ± 0.78, P < 0.05). LDL/HDL ratio was significantly associated with the severity of coronary vascular stenosis. The area under the ROC curve of LDL-C, HDL-C, LDL/HDL ratio used to predict CAHD are 0.574 (95% CI 0.547-0.600, P < 0.001), 0.625 (95% CI 0.598-0.651, P < 0.001), 0.668 (95% CI 0.639-0.697, P = 0.000), respectively. The cut-off value of LDL/HDL ratio is 2.517, and the sensitivity and specificity are 65% and 61%, respectively. LDL/HDL ratio was related to the prevalence of CAHD and the odds ratio (OR) was 2.39 [95% confidence interval (CI) 1.698-2.593, P = 0.00] in multicollinearity regression model.
conclusionLDL/HDL ratio may become a better predictor of CAHD severity, compared to LDL-C or HDL-C.
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