ArticleScientific reports2022
Effects of Wolbachia elimination and B-vitamin supplementation on bed bug development and reproduction.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 31 citations in OpenAlex.
- Temperature-sensitive cytoplasmic incompatibility across divergent Wolbachia partly reflects cifB transcription, not endosymbiont density.Molecular biology and evolution · 2026Article
- Temperature-sensitive cytoplasmic incompatibility across divergentbioRxiv : the preprint server for biology · 2026Article
- Evolution, multifunctionality, and agricultural potential of insect microbiomes and the holobiont concept.The ISME journal · 2026Review
- Pseudoalteromonas is a symbiont of marine invertebrates that exhibits broad patterns of phylosymbiosis.The ISME journal · 2026Article
- Article
- Ghosts of symbionts past: the hidden history of the dynamic association between filarial nematodes and their Wolbachia endosymbionts.G3 (Bethesda, Md.) · 2025Article
- Wolbachia-supplemented B-vitamins are critical for blood digestion in the bed bug Cimex lectularius.Scientific reports · 2025Article
- Primary and Secondary Symbionts of Cambodian Cicadellidae and the Role of Parasitisation.Environmental microbiology reports · 2025Article
- Article
- Impact of rising temperatures on the bacterial communities of Aphaenogaster ants.Biology open · 2025Article
- Counting rareMicrobiology spectrum · 2025Article
- Invasive indoor pests under the microbiological lens: bacterial and viral diversity from local to global scales in bed bugs and cockroaches.Current opinion in insect science · 2025Review
- Abundance of the Dominant EndosymbiontInsects · 2025Article
- Article
- Prevalence of Heritable Symbionts in Parisian Bedbugs (Hemiptera: Cimicidae).Environmental microbiology reports · 2025Article
- Comparative Transcriptomics of Fat Bodies between Symbiotic and Quasi-Aposymbiotic Adult Females ofInternational journal of molecular sciences · 2024Article
- Wolbachia supergroup A in Enoplognatha latimana (Araneae: Theridiidae) in Poland as an example of possible horizontal transfer of bacteria.Scientific reports · 2024Article
- Evolutionary history of tyrosine-supplementing endosymbionts in pollen-feeding beetles.The ISME journal · 2024Article
- Wolbachia: Advancing into a Second Century.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Development, feeding, and sex shape the relative quantity of the nutritional obligatory symbiontFrontiers in microbiology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Obligate blood feeders, such as Cimex lectularius (common bed bug), have symbiotic associations with nutritional endosymbionts that produce B-vitamins. To quantify the symbiont's contribution to host fitness in these obligate mutualisms, the symbiont must be eliminated and its absence rigorously confirmed. We developed and validated procedures for complete elimination of Wolbachia (Wb) in bed bugs and quantified development and reproduction in bed bugs with and without Wb and with and without B-vitamins supplementation. Aposymbiotic bed bugs had slower nymphal development, reduced adult survivorship, smaller adult size, fewer eggs per female, and lower hatch rate than bed bugs that harbored Wb. In aposymbiotic bed bugs that were fed B-vitamins-supplemented blood, nymph development time, adult survivorship and hatch rate recovered to control levels, but adult size and egg number only partially recovered. These results underscore the nutritional dependence of bed bugs on their Wb symbiont and suggest that Wb may provide additional nutritional benefits beyond the B-vitamin mix that we investigated.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.