ArticleBritish journal of cancer2022
Gallstones and risk of cancers of the liver, biliary tract and pancreas: a prospective study within two U.S. cohorts.
Article in British journal of cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Association Between Gallstone Disease and Risk of Mortality of Cardiovascular Disease and Cancer: A Systematic Review and Meta-Analysis.Cardiovascular & hematological disorders drug targets · 2024Pooled it
- Burden of gallbladder and biliary tract cancer (GBTC) in the middle east and North Africa (MENA) from 1990 to 2021: from the global burden of disease (GBD).Annals of medicine and surgery (2012) · 2026Article
- The modified cardiometabolic index is associated with gallstones in US adults: a cross-sectional analysis.Medicine · 2026Article
- The relationship between serum uric acid and gallbladder stones in Korean women: a cross-sectional study of 19,329 cases.BMC gastroenterology · 2026Article
- Better adherence to the life's essential 8 can reduce the risk of gallstone disease: mediated by inflammation and oxidative stress.Frontiers in public health · 2026Article
- Evaluating the liver fibrosis and waist-to-height ratio(LFWHR) as a gallstone disease predictor: a nomogram model and SHAP analysis.Scientific reports · 2025Article
- Trends and projections of gallbladder and biliary tract cancer in China: a comprehensive analysis from 1990 to 2030 based on the Global Burden of Disease Study 2021.BMC public health · 2025Article
- Association of dietary vitamin intake with gallstone risk in US adults: a cross-sectional NHANES study.European journal of medical research · 2025Article
- Association between sarcopenia and the prevalence of gallstone in US adults: a cross-sectional analysis of NHANES.BMC gastroenterology · 2025Article
- Oxidative balance scores and gallstone disease: mediating effects of oxidative stress.Nutrition journal · 2025Article
- Burden and risk factors for gallbladder and biliary tract diseases in China from 1990 to 2021 and burden predictions of risk factors for the next 15 years.Frontiers in medicine · 2025Article
- Associations of self-reported sleep disturbances, sleep onset, and duration with gallstone disease risk.Frontiers in nutrition · 2025Article
- Association between osteoporosis and gallstone based on the National Health and Nutrition Examination Survey (NHANES) 2017-2020: a cross-sectional study.Frontiers in public health · 2025Article
- Liver Cancer Etiology: Old Issues and New Perspectives.Current oncology reports · 2024Review
- Association of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and gallstones among US adults aged ≤ 50 years: a cross-sectional study from NHANES 2017-2020.Lipids in health and disease · 2024Article
- Association between life-ever gallstones and depressive symptoms in U.S. adults: a cross-sectional study.Scientific reports · 2024Article
- Pancreatic Cancer: A Review of Risk Factors.Life (Basel, Switzerland) · 2024Review
- Investigating the association between blood cobalt and gallstones: a cross-sectional study utilizing NHANES data.Frontiers in public health · 2024Article
- The correlation between urinary iodine levels and gallstone risk: elevated iodine intake linked to gallstone occurrence.Frontiers in nutrition · 2024Article
- Longitudinal Study of Comorbidities and Clinical Outcomes in Persons with Gallstone Disease Using Electronic Health Records.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2023Article
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Authors and funding
16 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundGallstones may result in inflammation, altered bile flow, and changes in metabolic hormone levels, thereby increasing cancer risk. However, previous studies for gallstones and cancers of the liver, biliary tract and pancreas in the U.S. were relatively limited.
methodsWe followed 115,036 women from the Nurses' Health Study (1982-2012) and 49,729 men from the Health Professionals Follow-up Study (1986-2012). History of gallstones, including with or without performed cholecystectomy, was reported at baseline and updated through biennial questionnaires. The Cox proportional hazard regression model was used to calculate multivariable hazard ratios (HRs) and 95% confidence intervals (95% CIs).
resultsDuring up to 30-year follow-up, we identified 204 incidents of liver cancer, 225 biliary tract cancer and 1147 pancreatic cancer cases. Compared to those without gallstones diagnosis, the multivariable HRs for individuals with gallstones (untreated or with cholecystectomy) were 1.60 for liver cancer (95% CI: 1.14-2.26), 4.79 for biliary tract cancer (95% CI: 3.02-7.58), and 1.13 for pancreatic cancer (95% CI: 0.96-1.32). The multivariable HRs for individuals with cholecystectomy were 1.33 for liver cancer (95% CI: 0.90-1.95) and 1.15 for pancreatic cancer (95% CI: 0.98-1.36).
conclusionsGallstones were associated with a higher risk of cancers of the liver, biliary tract and possibly pancreas.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.