Evidence map›Paper›PMID 35715591›Full record

ArticleInflammation2022

ALDH2 Hampers Immune Escape in Liver Hepatocellular Carcinoma through ROS/Nrf2-mediated Autophagy.

Jingyao Hu, Liang Yang, Xueqiang Peng, Minghuan Mao, Xiaodan Liu, Jianbo Song, Hangyu Li

Abstract read
PubMed Publisher
In one paragraph

Article in Inflammation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
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  7. The Regulatory Role ofAntioxidants (Basel, Switzerland) · 2025
    Article
  8. Review
  9. Article
  10. [Research progress of aldehyde dehydrogenase type 2 in head and neck malignant tumors].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025
    Review
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  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jingyao HuThe Fourth Department of General Surgery, The Fourth Affiliated Hospital of China Medical University, Huanggu District, No. 4, Chongshan East Road, 110000, Liaoning, People's Republic of China. jyhu@cmu.edu.cn.ORCID http://orcid.org/0000-0002-6799-3620
Liang YangThe Third Department of General Surgery, The Fourth Affiliated Hospital of China Medical University, 110000, Liaoning, People's Republic of China.
Xueqiang PengThe Third Department of General Surgery, The Fourth Affiliated Hospital of China Medical University, 110000, Liaoning, People's Republic of China.
Minghuan MaoThe Fourth Department of General Surgery, The Fourth Affiliated Hospital of China Medical University, Huanggu District, No. 4, Chongshan East Road, 110000, Liaoning, People's Republic of China.
Xiaodan LiuThe Fifth Department of General Surgery, The Fourth Affiliated Hospital of China Medical University, 110000, Liaoning, People's Republic of China.
Jianbo SongInterventional Department, The Fourth Affiliated Hospital of China Medical University, 110000, Liaoning, People's Republic of China.
Hangyu LiThe Third Department of General Surgery, The Fourth Affiliated Hospital of China Medical University, 110000, Liaoning, People's Republic of China. sj_li_hangyu@sina.com.
Fourth Affiliated Hospital of China Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aldehyde dehydrogenase 2 (ALDH2) has been implicated in the progression of liver hepatocellular carcinoma (LIHC). The most important feature of LIHC is the immune escape process. This study sets to study the role of ALDH2 in regulating immune escape in LIHC. Bioinformatics analysis was applied to examine the expression of ALDH2 in LIHC and its impact on patients' survival. The effect of ALDH2 expression on malignant phenotype of LIHC cells was assessed by gain-of-function assays. RT-qPCR and Western blot were conducted to examine the expression of related factors, thus investigating the downstream mechanisms of ALDH2. ELISA assay was carried out to measure the level of oxidative stress in cells, and crystal violet staining was conducted to observe the killing effect of T cells on tumor cells. Finally, xenograft assay was carried out to verify the role of ALDH2 in vivo.ALDH2 was poorly expressed in LIHC, which predicted dismal prognoses for patients. ALDH2 inhibited the malignant aggressiveness of LIHC cells. ALDH2 blocked the activation of Nrf2 by suppressing reactive oxygen species (ROS) in LIHC, and Nrf2 significantly reversed the tumor-suppressing properties of ALDH2. Nrf2 hindered autophagy and led to immune escape of LIHC cells. Moreover, ALDH2 considerably suppressed the growth of xenografts, increased autophagy and promoted the accumulation of T cells in tumors. In contrast, Nrf2 drastically reversed the repressive effect of ALDH2 on tumor growth.ALDH2 impaired the ROS/Nrf2 axis to promote autophagy, thereby repressing immune escape in LIHC.

Indexed as

Aldehyde Dehydrogenase, MitochondrialAutophagyCarcinoma, HepatocellularLiver NeoplasmsTumor EscapeHumansNF-E2-Related Factor 2Reactive Oxygen SpeciesAldehyde Dehydrogenase, MitochondrialALDH2 protein, humanNF-E2-Related Factor 2Reactive Oxygen SpeciesALDH2AutophagyImmune escapeLiver hepatocellular carcinomaNrf2

Identifiers

PMID35715591
OpenAlexW4283069909

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.