ArticleScientific reports2022
Imaging peripheral nerve micro-anatomy with MUSE, 2D and 3D approaches.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Computational Morphometry of Peripheral Nerves: A Pipeline Perspective on Reproducibility and Generalization.Neuroinformatics · 2026Review
- Advances in multiscale myelin imaging: from classical histology to functional insights.Frontiers in cellular neuroscience · 2026Review
- Phase-Specific Evaluation of Sciatic Nerve Regeneration in Preclinical Studies: A Review of Functional Assessment, Emerging Therapies, and Translational Value.International journal of molecular sciences · 2025Review
- The human vagal complex: from gross anatomy to single neurons, from brainstem to abdomen.Research square · 2025Article
- 3D-Printing of Electroconductive MXene-Based Micro-Meshes in a Biomimetic Hyaluronic Acid-Based Scaffold Directs and Enhances Electrical Stimulation for Neural Repair Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Wavelet-based compression method for scale-preserving in VNIR and SWIR hyperspectral data.Journal of medical imaging (Bellingham, Wash.) · 2025Article
- Maximum contrast projection: A powerful tool for biomedical image stack analysis.Journal of neuropathology and experimental neurology · 2025Article
- Label-free full-thickness imaging of porcine vagus nerve fascicular anatomy by polarization-sensitive optical coherence tomography.Journal of neural engineering · 2025Article
- Few-shot segmentation and fiber tractography of human vagus nerve using 3D-MUSE imaging.Proceedings of SPIE--the International Society for Optical Engineering · 2025Article
- Fascicle differentiation of upper extremity nerves on high-resolution ultrasound with multimodal microscopic verification.Scientific reports · 2025Article
- Establishment of a Serum-Free Human iPSC-Derived Model of Peripheral Myelination.ACS biomaterials science & engineering · 2024Article
- NerveTracker: a Python-based software toolkit for visualizing and tracking groups of nerve fibers in serial block-face microscopy with ultraviolet surface excitation images.Journal of biomedical optics · 2024Article
- An end-to-end workflow for nondestructive 3D pathology.Nature protocols · 2024Review
- Human microscopic vagus nerve anatomy using deep learning on 3D-MUSE images.Proceedings of SPIE--the International Society for Optical Engineering · 2024Article
- Visualization of Gastric Adenocarcinoma Lymph Node Metastases by Microscopy with Ultraviolet Surface Excitation.Sovremennye tekhnologii v meditsine · 2024Article
- Quantification of porcine lower thoracic spinal cord morphology with intact dura mater using high-resolution μCT.Journal of neuroimaging : official journal of the American Society of NeuroimagingArticle
- Phosphotungstic Acid Staining to Visualize the Vagus Nerve Perineurium Using Micro-CT.Journal of neuroimaging : official journal of the American Society of NeuroimagingArticle
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Authors and funding
11 authors.
Funding
Abstract
Understanding peripheral nerve micro-anatomy can assist in the development of safe and effective neuromodulation devices. However, current approaches for imaging nerve morphology at the fiber level are either cumbersome, require substantial instrumentation, have a limited volume of view, or are limited in resolution/contrast. We present alternative methods based on MUSE (Microscopy with Ultraviolet Surface Excitation) imaging to investigate peripheral nerve morphology, both in 2D and 3D. For 2D imaging, fixed samples are imaged on a conventional MUSE system either label free (via auto-fluorescence) or after staining with fluorescent dyes. This method provides a simple and rapid technique to visualize myelinated nerve fibers at specific locations along the length of the nerve and perform measurements of fiber morphology (e.g., axon diameter and g-ratio). For 3D imaging, a whole-mount staining and MUSE block-face imaging method is developed that can be used to characterize peripheral nerve micro-anatomy and improve the accuracy of computational models in neuromodulation. Images of rat sciatic and human cadaver tibial nerves are presented, illustrating the applicability of the method in different preclinical models.
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Registered trials
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