Evidence map›Paper›PMID 35715504›Full record

ReviewNature medicine2022

Redefining critical illness.

David M Maslove, Benjamin Tang, Manu Shankar-Hari, Patrick R Lawler, Derek C Angus, J Kenneth Baillie, Rebecca M Baron, Michael Bauer, Timothy G Buchman, Carolyn S Calfee and 29 more

4 registry-linked trialsOpen access · bronzeAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 222 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
222citing papers in PubMed, 4 pooled it
50.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05591924 recruitingnot on this mapstarted 2024, after this paper: background citation

Prospective Observational Study of Biology of Critical Illness

Typeobservational_patient_registrySponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2024 to 2034Enrolled1,000ConditionsSepsis, ARDS, Critical Illness, Neurocognitive DysfunctionArmsPhelebotomy, Broncheoalveolar Lavage, Tracheal Aspirate, Rectal Swab
NCT05728359 recruitingnot on this map

Prospective Observational Study Investigating Genomic Determinants of Outcome From Cardiogenic Shock (GOlDilOCS)

Typeobservational_patient_registrySponsorBarts & The London NHS TrustRan2022 to 2026Enrolled300ConditionsCardiogenic ShockArmsObservational study
NCT06539234 recruitingnot on this mapstarted 2024, after this paper: background citation

Angiotensin II Stress Test. Renin Kinetics During Treatment of Vasoplegic Shock With Angiotensin II in Relation to Hemodynamic Response to Treatment With Angiotensin II.

TypeobservationalSponsorUniversity Medical Centre MariborRan2024 to 2026Enrolled80ConditionsShock, Vasoplegic Syndrome
NCT07779642 phase2not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Precision Medicine Adaptive Network Platform Trial in Hypoxemic Acute Respiratory Failure

TypeinterventionalSponsorUniversity of Colorado, DenverRan2026 to 2030Enrolled300ConditionsARDS (Acute Respiratory Distress Syndrome), Acute Hypoxic Respiratory FailureArmsSimvastatin, Baricitinib
3 · Its place in the literature

Who cites it

222 citing papers in PubMed, 4 syntheses or guidelines pooled it, 334 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Molecular Phenotyping of Sepsis and Differential Response to Fluid Resuscitation.American journal of respiratory and critical care medicine · 2025
    Trial
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Body mass index and hospital mortality in mechanically ventilated patients with acute hypoxaemic respiratory failure: A retrospective cohort study.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2026
    Article
  12. [Personalized sepsis therapy and modern trial designs].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2026
    Article
  13. Observational
  14. Article
  15. Review
  16. Article
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  20. Observational

162 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

39 authors at 20 institutions in 7 countries.

David M Maslove *Department of Critical Care Medicine, Queen's University, Kingston, Ontario, Canada. david.maslove@queensu.ca.ORCID http://orcid.org/0000-0002-0765-7158
Benjamin Tang *Department of Intensive Care Medicine, Nepean Hospital, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0002-1469-9540
Manu Shankar-HariThe Queen's Medical Research Institute, Centre for Inflammation Research, Institute for Regeneration and Repair, Edinburgh, UK.ORCID http://orcid.org/0000-0002-5338-2538
Patrick R LawlerCardiac Intensive Care Unit, Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada.
Derek C AngusDepartment of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
J Kenneth BaillieIntensive Care Medicine, Royal Infirmary of Edinburgh, NHS Lothian, Edinburgh, UK.ORCID http://orcid.org/0000-0001-5258-793X
Rebecca M BaronDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Michael BauerDepartment of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany.ORCID http://orcid.org/0000-0002-1521-3514
Timothy G BuchmanEmory Critical Care Center, Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0001-7350-5921
Carolyn S CalfeeDivision of Pulmonary, Critical Care, Allergy, and Sleep Medicine; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Claudia C Dos SantosInterdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada.
Evangelos J Giamarellos-Bourboulis4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece.ORCID http://orcid.org/0000-0003-4713-3911
Anthony C GordonDivision of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-0419-547X
John A KellumDepartment of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0003-1995-2653
Julian C KnightWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Aleksandra LeligdowiczDepartment of Medicine, Division of Critical Care, University of Western Ontario, London, Ontario, Canada.ORCID http://orcid.org/0000-0001-6055-4644
Daniel F McAuleyRegional Intensive Care Unit, Royal Victoria Hospital, Belfast, UK.ORCID http://orcid.org/0000-0002-3283-1947
Anthony S McLeanDepartment of Intensive Care Medicine, Nepean Hospital, Sydney, New South Wales, Australia.
David K MenonDivision of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-3228-9692
Nuala J MeyerDepartment of Medicine, Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-4597-5584
Lyle L MoldawerSepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, Gainesville, FL, USA.
Kiran ReddyRegional Intensive Care Unit, Royal Victoria Hospital, Belfast, UK.ORCID http://orcid.org/0000-0002-1621-1481
John P ReillyDepartment of Medicine, Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-3937-5320
James A RussellCentre for Heart Lung Innovation and Critical Care Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Jonathan E SevranskyEmory Critical Care Center, Emory University, Atlanta, GA, USA.
Christopher W SeymourDepartment of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Nathan I ShapiroHarvard Medical School, Boston, MA, USA.
Mervyn SingerBloomsbury Institute of Intensive Care Medicine, Division of Medicine, University College London, London, UK.ORCID http://orcid.org/0000-0002-1042-6350
Charlotte SummersDepartment of Medicine, University of Cambridge School of Medicine, Cambridge, UK.ORCID http://orcid.org/0000-0002-7269-2873
Timothy E SweeneyInflammatix, Inc, Burlingame, CA, USA.
B Taylor ThompsonHarvard Medical School, Boston, MA, USA.
Tom van der PollAmsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.ORCID http://orcid.org/0000-0002-9199-5079
Balasubramanian VenkateshDepartment of Intensive Care, Wesley and Princess Alexandra Hospitals, Brisbane, Queensland, Australia.
Keith R WalleyCentre for Heart Lung Innovation and Critical Care Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Timothy S WalshUsher Institute for Population Health Sciences, Deanery of Molecular, Genetics, and Population Health Sciences, University of Edinburgh, Edinburgh, UK.
Lorraine B WareDepartments of Medicine and Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA.
Hector R WongDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID http://orcid.org/0000-0001-7989-1173
Zsolt E ZadorDepartment of Surgery, University of Toronto, Toronto, Ontario, Canada.
John C MarshallInterdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada.
University of Pittsburgh · USNepean Hospital · AUNHS Lothian · GBQueen's University Belfast · GBUniversity of British Columbia · CAUniversity of Cambridge · GBUniversity of Pennsylvania · USAmsterdam University Medical Centers · NLBeth Israel Deaconess Medical Center · USBrigham and Women's Hospital · USBury College · GBCentre for Human Genetics · GBCincinnati Children's Hospital Medical Center · USEmory University · USHarvard University · USImperial College London · GBJena University Hospital · DENational and Kapodistrian University of Athens · GRPrincess Alexandra Hospital · AUQueen's University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Research and practice in critical care medicine have long been defined by syndromes, which, despite being clinically recognizable entities, are, in fact, loose amalgams of heterogeneous states that may respond differently to therapy. Mounting translational evidence-supported by research on respiratory failure due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection-suggests that the current syndrome-based framework of critical illness should be reconsidered. Here we discuss recent findings from basic science and clinical research in critical care and explore how these might inform a new conceptual model of critical illness. De-emphasizing syndromes, we focus on the underlying biological changes that underpin critical illness states and that may be amenable to treatment. We hypothesize that such an approach will accelerate critical care research, leading to a richer understanding of the pathobiology of critical illness and of the key determinants of patient outcomes. This, in turn, will support the design of more effective clinical trials and inform a more precise and more effective practice at the bedside.

Indexed as

COVID-19Critical CareCritical IllnessHumansSyndrome

Identifiers

PMID35715504
OpenAlexW4283022274

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.