Evidence map›Paper›PMID 35715465›Full record

ArticleScientific reports2022

Diethyl phthalate (DEP) perturbs nitrogen metabolism in Saccharomyces cerevisiae.

Corinna Jie Hui Goh, Liang Cui, Jin Huei Wong, Jacqueline Lewis, Megan Goh, Kiat Whye Kong, Lay Kien Yang, Mohammad Alfatah, Yoganathan Kanagasundaram, Shawn Hoon and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Corinna Jie Hui GohBioinformatics Institute, 30 Biopolis Street, Singapore, 138671, Singapore.
Liang CuiAntimicrobial Resistance Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology, 1 CREATE Way, Singapore, 138602, Singapore.
Jin Huei WongBioinformatics Institute, 30 Biopolis Street, Singapore, 138671, Singapore.
Jacqueline LewisSingapore Institute of Food and Biotechnology Innovation, 61 Biopolis Drive, Singapore, 138673, Singapore.
Megan GohSingapore Institute of Food and Biotechnology Innovation, 61 Biopolis Drive, Singapore, 138673, Singapore.
Kiat Whye KongInstitute of Molecular and Cellular Biology, 61 Biopolis Drive, Singapore, 138673, Singapore.
Lay Kien YangSingapore Institute of Food and Biotechnology Innovation, 61 Biopolis Drive, Singapore, 138673, Singapore.
Mohammad AlfatahBioinformatics Institute, 30 Biopolis Street, Singapore, 138671, Singapore.
Yoganathan KanagasundaramSingapore Institute of Food and Biotechnology Innovation, 61 Biopolis Drive, Singapore, 138673, Singapore.
Shawn HoonInstitute of Molecular and Cellular Biology, 61 Biopolis Drive, Singapore, 138673, Singapore.
Prakash ArumugamSingapore Institute of Food and Biotechnology Innovation, 61 Biopolis Drive, Singapore, 138673, Singapore. parumugam@sifbi.a-star.edu.sg.
Bioinformatics Institute · SGInstitute of Molecular and Cell Biology · SGNanyang Technological University · SGSingapore-MIT Alliance for Research and Technology · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phthalates are ubiquitously used as plasticizers in various consumer care products. Diethyl phthalate (DEP), one of the main phthalates, elicits developmental and reproductive toxicities but the underlying mechanisms are not fully understood. Chemogenomic profiling of DEP in S. cerevisiae revealed that two transcription factors Stp1 and Dal81 involved in the Ssy1-Ptr5-Ssy5 (SPS) amino acid-sensing pathway provide resistance to DEP. Growth inhibition of yeast cells by DEP was stronger in poor nitrogen medium in comparison to nitrogen-rich medium. Addition of amino acids to nitrogen-poor medium suppressed DEP toxicity. Catabolism of amino acids via the Ehrlich pathway is required for suppressing DEP toxicity. Targeted metabolite analyses showed that DEP treatment alters the amino acid profile of yeast cells. We propose that DEP inhibits the growth of yeast cells by affecting nitrogen metabolism and discuss the implications of our findings on DEP-mediated toxic effects in humans.

Indexed as

Phthalic AcidsSaccharomyces cerevisiae ProteinsAmino AcidsHumansNitrogenNuclear ProteinsRNA-Binding ProteinsSaccharomyces cerevisiaeTranscription FactorsAmino Acidsdiethyl phthalateNitrogenNuclear ProteinsPhthalic AcidsRNA-Binding ProteinsSaccharomyces cerevisiae ProteinsSTP1 protein, S cerevisiaeTranscription Factors

Identifiers

PMID35715465
PMCPMC9205984
OpenAlexW4283008364

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.