Evidence map›Paper›PMID 35715406›Full record

ArticleNature communications2022

3D structure and in situ arrangements of CatSper channel in the sperm flagellum.

Yanhe Zhao, Huafeng Wang, Caroline Wiesehoefer, Naman B Shah, Evan Reetz, Jae Yeon Hwang, Xiaofang Huang, Tse-En Wang, Polina V Lishko, Karen M Davies and 3 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
8.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
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  7. Review
  8. Article
  9. Article
  10. Molecular basis of the higher-order assembly of CatSper.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. Molecular contacts in self-assembling clusters of membrane proteins.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  15. Article
  16. Dynamic relocation of PKA regulatory subunits during sperm capacitation: Linking PKA to the CatSper signaling complex.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  17. Article
  18. Unraveling atomic complexity from frozen samples.Structural dynamics (Melville, N.Y.) · 2025
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Yanhe Zhao *Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Huafeng Wang *Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT, 06510, USA.ORCID 0000-0002-7326-4379
Caroline WiesehoeferDepartment of Anatomy, University of Duisburg-Essen, Medical Faculty, 45147, Essen, Germany.ORCID 0000-0002-7174-9954
Naman B ShahDepartment of Molecular and Cell Biology, University of California, Berkeley, CA, 94720, USA.
Evan ReetzDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Jae Yeon HwangDepartment of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT, 06510, USA.
Xiaofang HuangDepartment of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT, 06510, USA.
Tse-En WangDepartment of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT, 06510, USA.
Polina V LishkoDepartment of Molecular and Cell Biology, University of California, Berkeley, CA, 94720, USA.ORCID 0000-0003-3140-2769
Karen M DaviesDepartment of Molecular and Cell Biology, University of California, Berkeley, CA, 94720, USA.
Gunther WennemuthDepartment of Anatomy, University of Duisburg-Essen, Medical Faculty, 45147, Essen, Germany.ORCID 0000-0003-3313-2475
Daniela NicastroDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. Daniela.Nicastro@UTSouthwestern.edu.ORCID 0000-0002-0122-7173
Jean-Ju ChungDepartment of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT, 06510, USA. jean-ju.chung@yale.edu.ORCID 0000-0001-8018-1355
Yale University · USLawrence Berkeley National Laboratory · USThe University of Texas Southwestern Medical Center · USUniversity of Duisburg-Essen · DEBuck Institute for Research on Aging · USSouthwestern Medical Center · US

Funding

Structure and Function of Complexes that Regulate Ciliary MotilityR01GM083122 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Daniela Nicastro · 2007 to 2026
$6.2M
CatSper regulation of sperm physiology and fertilityR01HD096745 · NICHD · YALE UNIVERSITY · PI Jean-Ju Lucia Chung · 2019 to 2026
$3.4M
Molecular identity of human sperm potassium channel and its role in male fertilityR01GM111802 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI LISHKO, POLINA V, SMITH, JAMES F. · 2015 to 2019
$2.2M
NICHD NIH HHS R01 HD096745NIGMS NIH HHS R01 GM083122NIGMS NIH HHS R01 GM111802
6 · The paper itself

Abstract

The sperm calcium channel CatSper plays a central role in successful fertilization as a primary Ca

Indexed as

Sperm MotilitySperm TailAnimalsCalciumCalcium ChannelsCell MembraneMaleMammalsMiceSpermatozoaCalciumCalcium Channels

Identifiers

PMID35715406
PMCPMC9205950
OpenAlexW4283029098

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.