Evidence map›Paper›PMID 35715336›Full record

ArticleBrazilian journal of otorhinolaryngology

Morphofunctional regeneration by mesenchymal stem cell and IGF-1 inoculation in a model of facial nerve crush injury in rats.

Aracele Gonçalves Vieira, Fausto Pierdona Guzen, José Rodolfo Lopes de Paiva, Lucídio Clebeson de Oliveira, Maria Clara de Araújo Jales, Eudes Euler de Souza Lucena, Virgínia Raquel Dos Santos Lucena, Hécio Henrique Araújo de Morais

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brazilian journal of otorhinolaryngology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Aracele Gonçalves VieiraUniversidade do Estado do Rio Grande do Norte, Mossoró, RN, Brazil.
Fausto Pierdona GuzenUniversidade do Estado do Rio Grande do Norte, Mossoró, RN, Brazil.
José Rodolfo Lopes de PaivaUniversidade do Estado do Rio Grande do Norte, Mossoró, RN, Brazil.
Lucídio Clebeson de OliveiraUniversidade do Estado do Rio Grande do Norte, Mossoró, RN, Brazil.
Maria Clara de Araújo JalesUniversidade Federal do Rio Grande do Norte, Escola Multicampi de Ciências Médicas, Caicó, RN, Brazil.
Eudes Euler de Souza LucenaUniversidade Federal do Rio Grande do Norte, Escola Multicampi de Ciências Médicas, Caicó, RN, Brazil.
Virgínia Raquel Dos Santos LucenaUniversidade Federal do Rio Grande do Norte, Escola Multicampi de Ciências Médicas, Caicó, RN, Brazil. Electronic address: virlucena@hotmail.com.
Hécio Henrique Araújo de MoraisUniversidade Federal do Rio Grande do Norte, Escola Multicampi de Ciências Médicas, Caicó, RN, Brazil.
Universidade do Estado do Rio Grande do Norte · BRUniversidade Federal do Rio Grande do Norte · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo analyze the morphofunctional regeneration process of facial nerve injury in the presence of insulin-like growth factor-1 and mesenchymal stem cells.

methodsFourteen Wistar rats suffered unilateral facial nerve crushing and were randomly divided into two groups. All received insulin-like growth factor-1 inoculation, but only half of the animals received an additional inoculation of mesenchymal stem cells. The animals were followed for 90 days and facial nerve regeneration was analyzed via spontaneous facial motor function tests and immunohistochemistry in the nerve motor nucleus.

resultsThe group that received the growth factor and stem cells showed a statistically superior mean in vibrissae movements (p < 0.01), touch reflex (p = 0.05) and eye closure (p < 0.01), in addition to better immunohistochemistry reactivity. There was a statistically significant difference in the mean number of cells in the facial nerve nucleus between the experimental groups (p = 0.025), with the group that received the growth factor and stem cells showing the highest mean.

conclusionThe association between growth factor and stem cells potentiates the morphofunctional regeneration of the facial nerve, occurring faster and more effectively. LEVEL OF EVIDENCE: 4, degree of recommendation C.

Indexed as

Crush InjuriesFacial Nerve InjuriesMesenchymal Stem CellsAnimalsFacial NerveInsulin-Like Growth Factor INerve RegenerationRatsRats, WistarInsulin-Like Growth Factor IFacial nerveGrowth factorsMesenchymal stem cells

Identifiers

PMID35715336
PMCPMC10071527
OpenAlexW4280551522

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.