Evidence map›Paper›PMID 35715171›Full record

ArticleTobacco control2023

Emerging ENDS products and challenges in tobacco control toxicity research.

Robert M Strongin, Eva Sharma, Hanno C Erythropel, Ahmad El-Hellani, Nada O F Kassem, Vladimir B Mikheev, Alexandra Noël, David H Peyton, Matthew L Springer

Open access · greenAbstract readEditorial
In one paragraph

Article in Tobacco control, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Young users of electronic cigarettes exhibit reduced cardiorespiratory fitness.Journal of applied physiology (Bethesda, Md. : 1985) · 2024
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 1 country.

Robert M StronginChemistry, Portland State University, Portland, Oregon, USA rmstrongin@gmail.com.ORCID 0000-0003-3777-8492
Eva SharmaBehavioral Health and Health Policy, Westat, Rockville, Maryland, USA.ORCID 0000-0002-1328-508X
Hanno C ErythropelChemical and Environmental Engineering, Yale University, New Haven, Connecticut, USA.ORCID 0000-0003-3443-9794
Ahmad El-HellaniCenter for Tobacco Research and the Division of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, Ohio, USA.
Nada O F KassemDivision of Health Promotion and Behavioral Science, San Diego State University Research Foundation, San Diego, California, USA.
Vladimir B MikheevBattelle Public Health Center for Tobacco Research, Battelle Memorial Institute, Columbus, Ohio, USA.
Alexandra NoëlDepartment of Comparative Biomedical Sciences, Louisiana State University, Baton Rouge, Louisiana, USA.
David H PeytonChemistry, Portland State University, Portland, Oregon, USA.ORCID 0000-0001-5828-055X
Matthew L SpringerDivision of Cardiology, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.ORCID 0000-0002-6689-8234
Portland State University · USBattelle · USLouisiana State University · USSan Diego State University · USUniversity of California, San Francisco · USVirginia Commonwealth University · USWestat (United States) · USYale University · US

Funding

Yale Center for the Study of Tobacco Product Use and Addiction (YCSTP) Project 2: Addictive Threshold of Nicotine and the Impact of SweetenersU54DA036151 · NIDA · YALE UNIVERSITY · PI LISA M FUCITO · 2018 to 2026
$41.6M
Leadership and Logistics CoreU54DA046060 · NIDA · WESTAT, INC. · PI Andrea M Stroup · 2018 to 2026
$28.1M
Project 4: Using a prospective cohort survey to test population-level predictions generated by Projects 1-3U54DA036105 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI FAGAN, PEBBLES · 2018 to 2022
$20.8M
PROJECT 5: IMPACT OF CHANGING TOBACCO PRODUCT USE ON HEALTHCARE COSTS FOR GENERAL AND VULNERABLE POPULATIONSU54HL147127 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LING, PAMELA MAY · 2018 to 2022
$20.4M
Toxicant Production and Mitigation in the Electronic-Cigarette Reaction VesselR01ES025257 · NIEHS · PORTLAND STATE UNIVERSITY · PI STRONGIN, ROBERT M · 2015 to 2019
$3.6M
Integrated risk assessment and molecular characterization of pulmonary response to e-cigarette exposureR01HL139335 · NHLBI · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI MIKHEEV, VLADIMIR B, QIAN, WEI-JUN · 2018 to 2021
$2.4M
Effect of third-generation electronic cigarettes design features on aerosol constituents and pulmonary toxicity in vitro and in vivoR03ES029441 · NIEHS · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI NOEL, ALEXANDRA · 2018 to 2020
$219k
NHLBI NIH HHS R01 HL139335NHLBI NIH HHS U54 HL147127NIDA NIH HHS U54 DA036105NIDA NIH HHS U54 DA036151NIDA NIH HHS U54 DA046060NIEHS NIH HHS R01 ES025257NIEHS NIH HHS R03 ES029441
6 · The paper itself

Abstract

Electronic nicotine delivery systems (ENDS) continue to rapidly evolve. Current products pose unique challenges and opportunities for researchers and regulators. This commentary aims to highlight research gaps, particularly in toxicity research, and provide guidance on priority research questions for the tobacco regulatory community. Disposable flavoured ENDS have become the most popular device class among youth and may contain higher nicotine levels than JUUL devices. They also exhibit enhanced harmful and potentially harmful constituents production, contain elevated levels of synthetic coolants and pose environmental concerns. Synthetic nicotine and flavour capsules are innovations that have recently enabled the circumvention of Food and Drug Administration oversight. Coil-less ENDS offer the promise of delivering fewer toxicants due to the absence of heating coils, but initial studies show that these products exhibit similar toxicological profiles compared with JUULs. Each of these topic areas requires further research to understand and mitigate their impact on human health, especially their risks to young users.

Indexed as

Electronic Nicotine Delivery SystemsTobacco ProductsAdolescentFlavoring AgentsHumansNicotineTobacco ControlFlavoring AgentsNicotineelectronic nicotine delivery devicesenvironmentnicotinepublic policytobacco industry

Identifiers

PMID35715171
PMCPMC9758272
OpenAlexW4283030223

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.