ArticleOsteoarthritis and cartilage2022
Effusion-synovitis worsening mediates the association between body mass index and Kellgren-Lawrence progression in obese individuals: data from the Osteoarthritis Initiative.
Article in Osteoarthritis and cartilage, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Obesity-Associated Osteoarthritis: Mechanical-Metabolic Pathogenesis, Obesity Memory and Dual-Target Therapy.Current obesity reports · 2026Review
- Associations of hemoglobin levels with structural knee MRI findings at 33 years of age in a general population-based birth cohort.Osteoarthritis and cartilage open · 2026Article
- Prevalence of knee radiographic and symptomatic osteoarthritis and ultrasound features across sex and body mass index groups: The Johnston County Health Study.Osteoarthritis and cartilage · 2026Article
- The role of the infrapatellar fat pad in osteoporotic knee osteoarthritis: bone-fat crosstalk: cross-sectional studies.Journal of orthopaedic surgery and research · 2025Article
- Association between body weight fluctuation and progression of radiographic knee osteoarthritis: a longitudinal cohort study.RMD open · 2025Article
- Synovitis mediates cartilage outcomes during weight-loss in knee osteoarthritis - 4-year follow-up data from the Osteoarthritis Initiative.Osteoarthritis and cartilage open · 2025Article
- Imaging-based measures of synovitis in knee osteoarthritis: A scoping review and narrative synthesis.Osteoarthritis and cartilage open · 2025Review
- Obesity and hyperlipidemia were associated with more severe synovitis and structural abnormalities as well as inferior functional outcomes in knee osteoarthritis: a retrospective comparative study.Journal of orthopaedic surgery and research · 2024Article
- Infrapatellar fat pad size and subcutaneous fat in knee osteoarthritis radiographic progression: data from the osteoarthritis initiative.Arthritis research & therapy · 2024Article
- Effect of weight loss on knee joint synovitis over 48 months and mediation by subcutaneous fat around the knee: data from the Osteoarthritis Initiative.BMC musculoskeletal disorders · 2024Article
- Article
- Molecular imaging for evaluation of synovitis associated with osteoarthritis: a narrative review.Arthritis research & therapy · 2024Review
- Update on recent developments in imaging of inflammation in osteoarthritis: a narrative review.Skeletal radiology · 2023Review
- Patient and provider radiation exposure during fluoroscopy guided chemical and thermal neurolysis of genicular nerves: A prospective cohort comparison study.Interventional pain medicine · 2022Article
- Latest advancements in imaging techniques in OA.Therapeutic advances in musculoskeletal disease · 2022Review
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveBoth obesity and synovitis are independently associated with knee osteoarthritis (KOA) progression. We examined whether synovitis mediates the relationship between body mass index (BMI) and KOA radiographic progression in the Osteoarthritis Initiative (OAI) cohort.
designWe conducted a case-control study within the OAI. Cases (n = 315) were right knees with an increase of ≥1 Kellgren-Lawrence from baseline to 48 months of follow-up. Controls (n = 315) were right knees with no KL change. Cases and controls were matched by age, sex, race, and baseline KL. MRI Osteoarthritis Knee Score (MOAKS) at baseline and at 2 years was used for a semi-quantitative scoring (0-3) of effusion-synovitis and Hoffa-synovitis. Conditional logistic regression estimated associations between BMI and synovitis with KOA progression. Mediation analysis was used to assess the mediating effects of synovitis.
resultsThe mean age of participants was 61 years, 70.8% were women, and 87% were White. KOA progression was associated with higher BMI (adjusted OR 1.05; 95%CI 1.01-1.09) and effusion-synovitis relative to no effusion-synovitis (adjusted OR 2.2; 95%CI 1.6-3.1). Associations between effusion-synovitis worsening and KOA progression were more pronounced among obese individuals (OR 34.1; 95%CI 4.2-274.8; P = 0.001) compared to normal weight (OR 3.2; 95%CI 0.8-12.8, P=0.096) individuals. Effusion-synovitis at 2 years, but not at baseline, mediated the relationship between BMI and KOA progression over a 4-year period.
conclusionsWe found that effusion-synovitis worsening mediated the association between BMI and KOA progression and was associated with increased risk of KOA progression, particularly among obese individuals.
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