Evidence map›Paper›PMID 35714603›Full record

ArticleDevelopmental cell2022

A functional circuit formed by the autonomic nerves and myofibroblasts controls mammalian alveolar formation for gas exchange.

Kuan Zhang, Erica Yao, Shao-An Wang, Ethan Chuang, Julia Wong, Liliana Minichiello, Andrew Schroeder, Walter Eckalbar, Paul J Wolters, Pao-Tien Chuang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. A Nerve-Fibroblast Axis in Mammalian Lung Fibrosis.bioRxiv : the preprint server for biology · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 3 countries.

Kuan ZhangCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA.
Erica YaoCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA.
Shao-An WangCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA; School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Ethan ChuangCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA.
Julia WongCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA.
Liliana MinichielloDepartment of Pharmacology, University of Oxford, Oxford OX1 3QT, UK.
Andrew SchroederGenomics CoLab, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Walter EckalbarGenomics CoLab, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Paul J WoltersDivision of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Pao-Tien ChuangCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: pao-tien.chuang@ucsf.edu.
University of California, San Francisco · USUniversity of Oxford · GB

Funding

Molecular mechanisms of alveolar development and regenerationR01HL142876 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHUANG, PAO-TIEN · 2018 to 2021
$2.1M
NHLBI NIH HHS R01 HL142876
6 · The paper itself

Abstract

Alveolar formation increases the surface area for gas exchange. A molecular understanding of alveologenesis remains incomplete. Here, we show that the autonomic nerve and alveolar myofibroblast form a functional unit in mice. Myofibroblasts secrete neurotrophins to promote neurite extension/survival, whereas neurotransmitters released from autonomic terminals are necessary for myofibroblast proliferation and migration, a key step in alveologenesis. This establishes a functional link between autonomic innervation and alveolar formation. We also discover that planar cell polarity (PCP) signaling employs a Wnt-Fz/Ror-Vangl cascade to regulate the cytoskeleton and neurotransmitter trafficking/release from the terminals of autonomic nerves. This represents a new aspect of PCP signaling in conferring cellular properties. Together, these studies offer molecular insight into how autonomic activity controls alveolar formation. Our work also illustrates the fundamental principle of how two tissues (e.g., nerves and lungs) interact to build alveoli at the organismal level.

Indexed as

MyofibroblastsPulmonary AlveoliAnimalsAutonomic PathwaysLungMammalsMiceOrganogenesisalveolar formationautonomic nerveschronic obstructive lung diseasecontraction/migrationgas exchangemyofibroblastsneurotransmittersneurotrophinsplanar cell polarity signalingproliferation

Identifiers

PMID35714603
PMCPMC9308505
OpenAlexW4283026917

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.