ArticlePhysics in medicine and biology2022
TOPAS-nBio simulation of temperature-dependent indirect DNA strand break yields.
Article in Physics in medicine and biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- TOPAS-nBio simulation of the impact of ultrahigh dose rate and oxygen concentration on the Fenton reaction using the Fricke solution.Medical physics · 2026Article
- Effect of FLASH dose-rate and oxygen concentration in the production of HPhysics in medicine and biology · 2025Article
- Investigation of hydrogen peroxide yields and oxygen consumption in high dose rate irradiation: a TOPAS-nBio Monte Carlo study.Physics in medicine and biology · 2024Article
- Modeling the oxygen effect in DNA strand break induced by gamma-rays with TOPAS-nBio.Physics in medicine and biology · 2024Article
- TOPAS-Tissue: A Framework for the Simulation of the Biological Response to Ionizing Radiation at the Multi-Cellular Level.International journal of molecular sciences · 2024Article
- Estimation of relative biological effectiveness ofEJNMMI physics · 2023Article
- GEANT4-DNA simulation of temperature-dependent and pH-dependent yields of chemical radiolytic species.Physics in medicine and biology · 2023Article
- An integrated Monte Carlo track-structure simulation framework for modeling inter and intra-track effects on homogenous chemistry.Physics in medicine and biology · 2023Article
- Radical Production with Pulsed Beams: Understanding the Transition to FLASH.International journal of molecular sciences · 2022Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Current Monte Carlo simulations of DNA damage have been reported only at ambient temperature. The aim of this work is to use TOPAS-nBio to simulate the yields of DNA single-strand breaks (SSBs) and double-strand breaks (DSBs) produced in plasmids under low-LET irradiation incorporating the effect of the temperature changes in the environment. A new feature was implemented in TOPAS-nBio to incorporate reaction rates used in the simulation of the chemical stage of water radiolysis as a function of temperature. The implemented feature was verified by simulating temperature-dependent
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.