Evidence map›Paper›PMID 35714583›Full record

ArticleMolecular cell2022

TADs do not stay in the loop.

Davide Michieletto, Wendy A Bickmore

Erratum issuedAbstract readComment
PubMed Publisher
In one paragraph

Article in Molecular cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Davide MichielettoSchool of Physics and Astronomy, Peter Guthrie Tait Road, University of Edinburgh, Edinburgh, UK; MRC Human Genetics Unit, Institute of Genetics and Cancer, Crewe Road, University of Edinburgh, Edinburgh, UK. Electronic address: davide.michieletto@ed.ac.uk.
Wendy A BickmoreMRC Human Genetics Unit, Institute of Genetics and Cancer, Crewe Road, University of Edinburgh, Edinburgh, UK. Electronic address: wendy.bickmore@ed.ac.uk.

Funding

Medical Research Council MC_UU_00007/2Wellcome Trust 212203
6 · The paper itself

Abstract

In a recent issue of Science, Gabriele et al. have, for the first time, quantified the dynamics of a topologically associating domain (TAD) in live cells by coupling super-resolution imaging and computational modelling, concluding that a TAD spends most of its life in a "partially extruded state" and that CTCF-CTCF loops are rare.

Indexed as

ChromatinCCCTC-Binding FactorCCCTC-Binding FactorChromatin

Identifiers

PMID35714583

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.