Evidence map›Paper›PMID 35714576›Full record

ArticleBiofabrication2022

Gravity-based patterning of osteogenic factors to preserve bone structure after osteochondral injury in a large animal model.

Hannah M Zlotnick, Ryan C Locke, Sanjana Hemdev, Brendan D Stoeckl, Sachin Gupta, Ana P Peredo, David R Steinberg, James L Carey, Daeyeon Lee, George R Dodge and 1 more

Open access · greenAbstract read
In one paragraph

Article in Biofabrication, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  5. Interfacial Tissue Regeneration with Bone.Current osteoporosis reports · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Hannah M ZlotnickDepartment of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, United States of America.ORCID 0000-0002-0942-3072
Ryan C LockeMcKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.ORCID 0000-0002-8466-3922
Sanjana HemdevMcKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.ORCID 0000-0002-6505-1023
Brendan D StoecklDepartment of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, United States of America.
Sachin GuptaMcKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.
Ana P PeredoDepartment of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, United States of America.ORCID 0000-0001-8383-039X
David R SteinbergMcKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.
James L CareyMcKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.
Daeyeon LeeDepartment of Chemical and Biomolecular Engineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, United States of America.ORCID 0000-0001-6679-290X
George R DodgeMcKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.
Robert L MauckDepartment of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, United States of America.ORCID 0000-0002-9537-603X
Philadelphia VA Medical Center · USUniversity of Pennsylvania · USUniversity of the Sciences · US

Funding

Overall: Resource-based Center for Musculoskeletal Disorders Research (Overall Application)P30AR069619 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI LOUIS J SOSLOWSKY · 2016 to 2026
$9.1M
Training Program in Musculoskeletal ResearchT32AR007132 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI Robert L Mauck, LOUIS J SOSLOWSKY · 1986 to 2026
$4.9M
Tunable Mechano-Activated Microcapsules for Therapeutic DeliveryR01AR071340 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI DODGE, GEORGE R., LEE, DAEYEON · 2017 to 2020
$1.4M
Magneto-patterned cartilage constructs for improved osteochondral integrationF31AR077395 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI ZLOTNICK, HANNAH MARIE · 2021 to 2022
$77k
Knee Joint Resurfacing with Anatomic Tissue Engineered Osteochondral ImplantsI01RX003375 · VA · PHILADELPHIA VA MEDICAL CENTER · PI MAUCK, ROBERT L, STEINBERG, DAVID · 2020 to 2024
–
RR&D Senior Research Career Scientist AwardIK6RX003416 · VA · PHILADELPHIA VA MEDICAL CENTER · PI Robert L Mauck · 2020 to 2026
–
NIAMS NIH HHS F31 AR077395NIAMS NIH HHS P30 AR069619NIAMS NIH HHS R01 AR071340NIAMS NIH HHS T32 AR007132RRD VA I01 RX003375RRD VA IK6 RX003416
6 · The paper itself

Abstract

Chondral and osteochondral repair strategies are limited by adverse bony changes that occur after injury. Bone resorption can cause entire scaffolds, engineered tissues, or even endogenous repair tissues to subside below the cartilage surface. To address this translational issue, we fabricated thick-shelled poly(D,L-lactide-co-glycolide) microcapsules containing the pro-osteogenic agents triiodothyronine and

Indexed as

Cartilage, ArticularOsteogenesisAnimalsBone and BonesCapsulesDisease Models, AnimalTissue EngineeringTissue ScaffoldsCapsulesanimal modelarticular cartilagebonecontrolled releasemicrocapsuleosteochondral interface

Identifiers

PMID35714576
PMCPMC9394087
OpenAlexW4283078007

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.