Evidence map›Paper›PMID 35714354›Full record

ArticleAstrobiology2022

Metagenome Analysis Reveals a Response of the Antibiotic Resistome to Mars-like Extraterrestrial Conditions.

Raffaella Sabatino, Tomasa Sbaffi, Gianluca Corno, Daniel Santana de Carvalho, Ana Paula Trovatti Uetanabaro, Aristóteles Góes-Neto, Olga Podolich, Natalia Kozyrovska, Jean-Pierre de Vera, Vasco Azevedo and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Astrobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 63% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 5 countries.

Raffaella SabatinoWater Research Institute (IRSA) - MEG Molecular Ecology Group, CNR - National Research Council of Italy, Verbania, Italy.
Tomasa SbaffiWater Research Institute (IRSA) - MEG Molecular Ecology Group, CNR - National Research Council of Italy, Verbania, Italy.
Gianluca CornoWater Research Institute (IRSA) - MEG Molecular Ecology Group, CNR - National Research Council of Italy, Verbania, Italy.
Daniel Santana de CarvalhoLaboratório de Biologia Molecular e Computacional de Fungos, Departamento de Genetica, Ecologia e Evolucao, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Ana Paula Trovatti UetanabaroLaboratório de Microbiologia Aplicada, Departamento de Ciências Biológicas, Universidade Estadual de Santa Cruz, Ilhéus, Brasil.
Aristóteles Góes-NetoLaboratório de Biologia Molecular e Computacional de Fungos, Departamento de Genetica, Ecologia e Evolucao, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Olga PodolichInstitute of Molecular Biology and Genetics of NASU, Kyiv, Ukraine.
Natalia KozyrovskaInstitute of Molecular Biology and Genetics of NASU, Kyiv, Ukraine.
Jean-Pierre de VeraGerman Aerospace Center (DLR), Space Operations and Astronaut Training, Microgravity User Support Center (MUSC), Cologne, Germany.
Vasco AzevedoLaboratório de Genética Celular e Molecular, Departamento de Genetica, Ecologia e Evolucao, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Debmalya BarhLaboratório de Genética Celular e Molecular, Departamento de Genetica, Ecologia e Evolucao, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Andrea Di CesareWater Research Institute (IRSA) - MEG Molecular Ecology Group, CNR - National Research Council of Italy, Verbania, Italy.
National Research Council · ITUniversidade Federal de Minas Gerais · BRInstitute of Molecular Biology and Genetics · UADeutsches Zentrum für Luft- und Raumfahrt e. V. (DLR) · DEUniversidade Estadual de Santa Cruz · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The spread of antibiotic resistance is becoming a serious global health concern. Numerous studies have been done to investigate the dynamics of antibiotic resistance genes (ARGs) in both indoor and outdoor environments. Nonetheless, few studies are available about the dynamics of the antibiotic resistome (total content of ARGs in the microbial cultures or communities) under stress in outer space environments. In this study, we aimed to experimentally investigate the dynamics of ARGs and metal resistance genes (MRGs) in Kombucha Mutualistic Community (KMC) samples exposed to Mars-like conditions simulated during the BIOMEX experiment outside the International Space Station with analysis of the metagenomics data previously produced. Thus, we compared them with those of the respective non-exposed KMC samples. The antibiotic resistome responded to the Mars-like conditions by enriching its diversity with ARGs after exposure, which were not found in non-exposed samples (

Indexed as

Anti-Bacterial AgentsMetagenomeDrug Resistance, MicrobialGenes, BacterialMetagenomicsAnti-Bacterial AgentsAntimicrobial resistanceExtraterrestrial environmentKombucha multimicrobial communityMetal resistance

Identifiers

PMID35714354
PMCPMC9508453
OpenAlexW4283077406

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.