ArticleMolecular biology and evolution2022
Functional Divergence of the bag-of-marbles Gene in the Drosophila melanogaster Species Group.
Article in Molecular biology and evolution, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 16 citations in OpenAlex.
- Orthologs of an essential orphan gene vary in their capacities for function and subcellular localization in Drosophila melanogaster.Molecular biology and evolution · 2026Article
- Comparative functional and evolutionary analysis of essential germline stem cell genes across the genus Drosophila and two outgroup species.G3 (Bethesda, Md.) · 2025Article
- Trade-off between antibacterial immune defense and oogenesis progression in female Drosophila melanogaster.Genetics · 2025Article
- Comparative Analysis of Drosophila Bam and Bgcn Sequences and Predicted Protein Structural Evolution.Journal of molecular evolution · 2025Article
- An orphan gene is essential for efficient sperm entry into eggs in Drosophila melanogaster.Genetics · 2025Article
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- An orphan gene is essential for efficient sperm entry into eggs inbioRxiv : the preprint server for biology · 2024Article
- Gene Protein Sequence Evolution Can Predict the Rapid Divergence of Ovariole Numbers in the Drosophila melanogaster Subgroup.Genome biology and evolution · 2024Article
- Evolution under a model of functionally buffered deleterious mutations can lead to positive selection in protein-coding genes.Evolution; international journal of organic evolution · 2023Article
- Wolbachia infection at least partially rescues the fertility and ovary defects of several new Drosophila melanogaster bag of marbles protein-coding mutants.PLoS genetics · 2023Article
- Higher-order epistasis shapes natural variation in germ stem cell niche activity.Nature communications · 2023Article
- Evolution of insect innate immunity through domestication of bacterial toxins.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In Drosophila melanogaster, a key germline stem cell (GSC) differentiation factor, bag of marbles (bam) shows rapid bursts of amino acid fixations between sibling species D. melanogaster and Drosophila simulans, but not in the outgroup species Drosophila ananassae. Here, we test the null hypothesis that bam's differentiation function is conserved between D. melanogaster and four additional Drosophila species in the melanogaster species group spanning approximately 30 million years of divergence. Surprisingly, we demonstrate that bam is not necessary for oogenesis or spermatogenesis in Drosophila teissieri nor is bam necessary for spermatogenesis in D. ananassae. Remarkably bam function may change on a relatively short time scale. We further report tests of neutral sequence evolution at bam in additional species of Drosophila and find a positive, but not perfect, correlation between evidence for positive selection at bam and its essential role in GSC regulation and fertility for both males and females. Further characterization of bam function in more divergent lineages will be necessary to distinguish between bam's critical gametogenesis role being newly derived in D. melanogaster, D. simulans, Drosophila yakuba, and D. ananassae females or it being basal to the genus and subsequently lost in numerous lineages.
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