Evidence map›Paper›PMID 35713933›Full record

Trial reportJournal of internal medicine2022

Aerobic exercise training and neurocognitive function in cognitively normal older adults: A one-year randomized controlled trial.

Takashi Tarumi, Neena R Patel, Tsubasa Tomoto, Evan Pasha, Ayaz M Khan, Kayla Kostroske, Jonathan Riley, Cynthia D Tinajero, Ciwen Wang, Linda S Hynan and 4 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of internal medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  12. One-year aerobic exercise increases cerebral blood flow in cognitively normal older adults.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Takashi TarumiInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, Texas, USA.ORCID 0000-0001-7061-8867
Neena R PatelInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, Texas, USA.
Tsubasa TomotoInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, Texas, USA.
Evan PashaInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, Texas, USA.
Ayaz M KhanInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, Texas, USA.
Kayla KostroskeInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, Texas, USA.
Jonathan RileyInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, Texas, USA.
Cynthia D TinajeroInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, Texas, USA.
Ciwen WangInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, Texas, USA.
Linda S HynanDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Karen M RodrigueCenter for Vital Longevity, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Dallas, Texas, USA.
Kristen M KennedyCenter for Vital Longevity, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Dallas, Texas, USA.
Denise C ParkCenter for Vital Longevity, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Dallas, Texas, USA.
Rong ZhangInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, Texas, USA.

Funding

Arterial Aging, Brain Perfusion & Exercise: Impact on Brain Structure & Function.R01HL102457 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI ZHANG, RONG · 2010 to 2013
$2.1M
NHLBI NIH HHS R01 HL102457NHLBI NIH HHS R01-HL-102457
6 · The paper itself

Abstract

backgroundCurrent evidence is inconsistent on the benefits of aerobic exercise training for preventing or attenuating age-related cognitive decline in older adults.

objectiveTo investigate the effects of a 1-year progressive, moderate-to-high intensity aerobic exercise intervention on cognitive function, brain volume, and cortical thickness in sedentary but otherwise healthy older adults.

methodsWe randomized 73 older adults to a 1-year aerobic exercise or stretching-and-toning (active control) program. The primary outcome was a cognitive composite score calculated from eight neuropsychological tests encompassing inductive reasoning, long-term and working memory, executive function, and processing speed. Secondary outcomes were brain volume and cortical thickness assessed by MRI, and cardiorespiratory fitness measured by peak oxygen uptake (VO

resultsOne-year aerobic exercise increased peak VO

conclusionsOne-year aerobic exercise and stretching interventions improved cognitive performance but did not prevent age-related brain volume loss in sedentary healthy older adults. Cardiorespiratory fitness gain was positively correlated with cognitive performance and regional cortical thickness.

Indexed as

Cognitive DysfunctionExerciseAgedCognitionExercise TherapyHumansNeuropsychological TestsOxygenOxygenaerobic exerciseagingbrain volume and cortical thicknesscardiorespiratory fitnessneurocognitive function

Identifiers

PMID35713933
PMCPMC9588521

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.