ArticleJournal of internal medicine2022
The risk of renal comorbidities in celiac disease patients depends on the phenotype of celiac disease.
Article in Journal of internal medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Therapeutic TG2 inhibition reverses systemic multiomic dysregulation in celiac disease.BMC medicine · 2026Trial
- A Literature Review of the Renal Manifestations in Pediatric Celiac Disease and Its Associated Clinical Implications.Cureus · 2025Review
- Factors influencing diagnostic delays in celiac disease.World journal of gastroenterology · 2025Article
- Coeliac disease: complications and comorbidities.Nature reviews. Gastroenterology & hepatology · 2025Review
- Genetic association between celiac disease and chronic kidney disease: a two-sample Mendelian randomization study.Renal failure · 2024Article
- Associations between Celiac Disease, Extra-Gastrointestinal Manifestations, and Gluten-Free Diet: A Narrative Overview.Nutrients · 2024Review
- Unraveling chronic kidney disease in children: a surprising manifestation of celiac disease.Frontiers in pediatrics · 2024Review
- Risk of vascular diseases in patients with dermatitis herpetiformis and coeliac disease: a long-term cohort study.Annals of medicine · 2023Article
- The risk of renal comorbidities in celiac disease patients depends on the phenotype of celiac disease.Journal of internal medicine · 2022Article
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11 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundAn increased risk of kidney disease in patients with celiac disease has been reported, but the association has remained obscure. Only few studies have investigated the association between renal comorbidities and dermatitis herpetiformis, a cutaneous manifestation of celiac disease.
objectivesWe investigated whether patients with different phenotypes of celiac disease are at higher risk of kidney diseases than age- and sex-matched references.
methodsThe diagnoses of glomerulonephritis, diabetic nephropathy, interstitial nephritis, and end-stage renal disease obtained from the National Hospital Discharge Register between 1970 and 2015 were identified in celiac disease (Marsh III, n = 1072) and dermatitis herpetiformis (n = 368) patients diagnosed at Tampere University Hospital catchment region and in 4296 reference subjects. Using the Cox proportional hazards model, we compared the risk of kidney diseases between patients and references. The study protocol was approved by the Regional Ethics Committee of Tampere University Hospital (R16090). As the study was register based, no consent from patients was required.
resultsEven after adjusting for type 1 diabetes, celiac disease was associated with an elevated risk of kidney disease (hazard ratio [HR] 1.85, 95% confidence interval [CI] 1.12-3.03), glomerulonephritis (HR 3.37, 95% CI 1.64-6.95), and IgA nephropathy (IgAN) (HR 18.98, 95% CI 2.29-157.63). No similarly elevated risk was found among dermatitis herpetiformis patients (HR 1.50, 95% CI 0.63-3.55; HR 2.21, 95% CI 0.77-6.38; and HR 5.87, 95% CI 0.53-64.79, respectively).
conclusionCeliac disease patients were at increased risk of kidney diseases, notably IgAN. The risk was dependent on the celiac disease phenotype and was not seen in patients with dermatitis herpetiformis. Awareness of possible renal manifestations is recommended when treating celiac disease patients.
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