Inferior Vena Cava Collapsibility Index: A Precise, Noninvasive Tool for Evaluation of Edema in Children with Nephrotic Syndrome.

Hanan El-Halaby, Ashraf Bakr, Mohamed El-Assmy, Hussein Abdelaziz Abdalla, Marwa Salem, Riham Eid

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Article in Indian journal of pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Hanan El-HalabyPediatric Intensive Care Unit, Pediatrics Department, Mansoura University Children's Hospital, Faculty of Medicine, Mansoura University, Mansoura, Egypt.ORCID 0000-0003-0654-3607

Ashraf BakrPediatric Nephrology Unit, Pediatrics Department, Mansoura University Children's Hospital, Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt.ORCID 0000-0001-6536-3820

Mohamed El-AssmyPediatric Intensive Care Unit, Pediatrics Department, Mansoura University Children's Hospital, Faculty of Medicine, Mansoura University, Mansoura, Egypt.ORCID 0000-0003-3798-5811

Hussein Abdelaziz AbdallaBiochemistry Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.ORCID 0000-0002-2120-2651

Marwa SalemPediatrics Department, Mansoura University Children's Hospital, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Riham EidPediatric Nephrology Unit, Pediatrics Department, Mansoura University Children's Hospital, Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt. rihameid@mans.edu.eg.ORCID 0000-0003-2193-9028

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to evaluate available volume status assessment tools in nephrotic syndrome (NS). Sixty children with INS were subdivided into hypovolemic and nonhypovolemic groups based on fractional excretion of sodium (FeNa%); all were studied for inferior vena cava collapsibility index (IVCCI), plasma atrial natriuretic peptide (ANP), and body composition monitor (BCM). Forty-four patients had nonhypovolemic and 16 had hypovolemic states. ANP did not differ between both groups. IVCCI was higher in hypovolemic group (p < 0.001) with sensitivity 87.5% and specificity 81.8% for hypovolemia detection, while BCM overhydration (BCM-OH) values were higher in nonhypovolemic group (p = 0.04) with sensitivity = 68.2% and specificity = 75% for detection of hypervolemia. FeNa% showed negative correlation with IVCCI (r = -0.578, p < 0.001) and positive correlation with BCM-OH (r = 0.33, p = 0.018), while FeNa% showed nonsignificant correlation to ANP concentration. IVCCI is a reliable tool for evaluating volume status in NS and is superior to BCM.

Indexed as

Nephrotic SyndromeVena Cava, InferiorAtrial Natriuretic FactorChildEdemaHumansHypovolemiaSodiumUltrasonographyAtrial Natriuretic FactorSodiumAtrial natriuretic peptideBody composition monitorChildrenInferior vena cavaIntravascular volumeNephrotic syndrome

Identifiers

PMID35713769

DOI10.1007/s12098-022-04177-1

PMCPMC9569288

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