ReviewJournal of assisted reproduction and genetics2022
Sperm cryopreservation and DNA methylation: possible implications for ART success and the health of offspring.
Review in Journal of assisted reproduction and genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Best practices for cryopreserving sperm in Nonhuman Primates: a systematic review and meta-analysis.Scientific reports · 2025Pooled it
- Fresh versus frozen-thawed testicular sperm for intracytoplasmic sperm injection in men with non-obstructive azoospermia: a systematic review and meta-analysis.Journal of assisted reproduction and genetics · 2026Review
- Transgenerational Epigenetic Effect of Cryopreservation of F0 Rooster Sperm (Animals : an open access journal from MDPI · 2026Article
- Do the children born after in vitro fertilization or intracytoplasmic sperm injection have poor intellectual performance? A prospective cohort study.BMC pregnancy and childbirth · 2026Article
- From Molecular Perturbations to Functional Decline: Multi-Omics Reveals Sperm Cryodamage in Sichuan Bream (Animals : an open access journal from MDPI · 2026Article
- The aging male: impact of aging on male reproduction.Biogerontology · 2025Review
- Semen cryopreservation and storage in liquid nitrogen: Impact on chromatin compaction.Andrology · 2025Article
- Sperm DNA methylation profiling in patients with Kallmann syndrome.Endocrine connections · 2025Article
- TdT/Cas12a-based biosensor for sensitive detection of DNA breakpoints in sperm cryopreservation.Scientific reports · 2025Article
- Correlation Analysis of Sperm Cryopreservation Quality with Serum Testosterone and Sperm gDNA Methylation Levels in Xiaoshan Chickens.Animals : an open access journal from MDPI · 2025Article
- The Effect of Edaravone Supplementation Prior to Cryopreservation on Sperm Parameters, DNA Integrity, Apoptosis, Lipid Peroxidation, and Mitochondrial Membrane Potential in Infertile Men with Asthenoteratozoospermia.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Animal Reproduction: Semen Quality Assessment, Volume II.Animals : an open access journal from MDPI · 2025Article
- Extender development for optimal cryopreservation of buck sperm to increase reproductive efficiency of goats.Frontiers in veterinary science · 2025Review
- Effect of Seminal Plasma on the Freezability of Boar Sperm.Animals : an open access journal from MDPI · 2024Article
- The storage time of cryopreserved human spermatozoa does not affect pathways involved in fertility.Basic and clinical andrology · 2024Article
- Effect of cholesterol-loaded cyclodextrin treatment on boar sperm cryopreservation.Animal bioscience · 2024Article
- DNA methylation patterns in patients with asthenospermia and oligoasthenospermia.BMC genomics · 2024Article
- Pyrroloquinoline Quinone Improves Ram Sperm Quality through Its Antioxidative Ability during Storage at 4 °C.Antioxidants (Basel, Switzerland) · 2024Article
- Cardiovascular health of offspring conceived by assisted reproduction technology: a comprehensive review.Frontiers in cardiovascular medicine · 2024Review
- A review on the functional roles of trehalose during cryopreservation of small ruminant semen.Frontiers in veterinary science · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the beneficial effects of sperm cryopreservation, increased reactive oxygen species (ROS) production during this process can affect spermatozoon structure and function. Moreover, ROS production is associated with elevated DNA damage and alterations in DNA methylation. There is little information about the effects of cryopreservation on epigenetic modulation in sperm and the health of children born with frozen spermatozoa. Considering the potential consequences of cryopreservation in ART-conceived children, it is necessary to assure that cryopreservation does not modify sperm DNA methylation status. This review summarizes reports on epigenetic modifications of spermatozoa during cryopreservation and the probable effects of this process on offspring health. Contradictory results have reported the influence of sperm cryopreservation on DNA methylation in imprinted genes. Multiclinical studies with larger sample sizes under the same conditions of cryopreservation and DNA methylation analysis are needed to make any definitive conclusion about the effect of the cryopreservation process on sperm DNA methylation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.