Evidence map›Paper›PMID 35713714›Full record

ReviewJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2022

Promising application of polyoxometalates in the treatment of cancer, infectious diseases and Alzheimer's disease.

Xuechen Wang, Shengnan Wei, Chao Zhao, Xin Li, Jin Jin, Xuening Shi, Zhenyue Su, Juan Li, Juan Wang

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 46 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Polyoxometalates bind multiple targets involved in Alzheimer's disease.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2025
    Article
  5. Article
  6. Current pharmaceutical design · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Polyoxometalates Impact as Anticancer Agents.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Xuechen Wang *School of Public Health, Jilin University, Changchun, Jilin, China.
Shengnan Wei *School of Public Health, Jilin University, Changchun, Jilin, China.
Chao ZhaoSchool of Public Health, Jilin University, Changchun, Jilin, China.
Xin LiSchool of Public Health, Jilin University, Changchun, Jilin, China.
Jin JinSchool of Public Health, Jilin University, Changchun, Jilin, China.
Xuening ShiSchool of Public Health, Jilin University, Changchun, Jilin, China.
Zhenyue SuSchool of Public Health, Jilin University, Changchun, Jilin, China.
Juan LiSchool of Public Health, Jilin University, Changchun, Jilin, China. li_juan@jlu.edu.cn.
Juan WangSchool of Public Health, Jilin University, Changchun, Jilin, China. jwang0723@jlu.edu.cn.
Jilin University · CN

Funding

Education Department of Jilin Province JJKH20221100KJFundamental Research Funds for the Central Universities 45121031D060National Natural Science Foundation of China 81872668National Natural Science Foundation of China 82073557National Natural Science Foundation of China 82073603
6 · The paper itself

Abstract

As shown in studies conducted in recent decades, polyoxometalates (POMs), as inorganic metal oxides, have promising biological activities, including antitumor, anti-infectious and anti-Alzheimer's activities, due to their special structures and properties. However, some side effects impede their clinical applications to a certain extent. Compared with unmodified POMs, POM-based inorganic-organic hybrids and POM-based nanocomposite structures show significantly enhanced bioactivity and reduced side effects. In this review, we introduce the biological activities of POMs and their derivatives and highlight the side effects of POMs on normal cells and organisms and their possible mechanisms of action. We then propose a development direction for overcoming their side effects. POMs are expected to constitute a new generation of inorganic metal drugs for the treatment of cancer, infectious diseases, and Alzheimer's disease.Graphical abstract.

Indexed as

Alzheimer DiseaseCommunicable DiseasesNeoplasmsTungsten CompoundsAnionsHumansPolyelectrolytesPolyoxometalatesAnionsPolyelectrolytesPolyoxometalatesTungsten CompoundsAlzheimer’s diseaseBiological activity; POMsCancerInfectious diseases

Identifiers

PMID35713714
PMCPMC9203773
OpenAlexW4283025014

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.