Evidence map›Paper›PMID 35713665›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2022

PET/CT imaging of CSF1R in a mouse model of tuberculosis.

Catherine A Foss, Alvaro A Ordonez, Ravi Naik, Deepankar Das, Andrew Hall, Yunkou Wu, Robert F Dannals, Sanjay K Jain, Martin G Pomper, Andrew G Horti

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 2 countries.

Catherine A FossThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, USA. cfoss1@jhmi.edu.ORCID 0000-0001-8870-5993
Alvaro A OrdonezDepartment of Pediatrics, Center for Infection and Inflammation Imaging Research, Baltimore, MD, USA.
Ravi NaikThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, USA.
Deepankar DasThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, USA.
Andrew HallThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, USA.
Yunkou WuThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, USA.
Robert F DannalsThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, USA.
Sanjay K JainThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, USA.
Martin G PomperThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, USA.
Andrew G HortiThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, USA.
Johns Hopkins University · US

Funding

Training/Dissemination-Resource for Molecular Imaging Agents in Precision MedicineP41EB024495 · NIBIB · UT SOUTHWESTERN MEDICAL CENTER · PI MARTIN G POMPER · 2017 to 2026
$11.8M
Preclinical modeling to study Tuberculous MeningitisR01AI145435 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2020 to 2024
$4.0M
Measuring Intralesional Drug Exposures in Cavitary TB using Noninvasive In Vivo PET ImagingR01AI153349 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2020 to 2024
$3.8M
Novel Imaging Tracers for Rapid and Noninvasive Assessment of Bacterial InfectionR01EB020539 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2014 to 2018
$3.6M
F-18 labelled PET tracer for imaging macrophage colony stimulating factor 1 receptor (CSF1R) in neuroinflammationR01AG066464 · NIA · JOHNS HOPKINS UNIVERSITY · PI HORTI, ANDREW G · 2020 to 2022
$1.8M
NIAID NIH HHS R01 AI145435NIAID NIH HHS R01 AI153349NIA NIH HHS R01 AG066464NIBIB NIH HHS P41 EB024495NIBIB NIH HHS R01 EB020539
6 · The paper itself

Abstract

purposeMacrophages represent an essential means of sequestration and immune evasion for Mycobacterium tuberculosis. Pulmonary tuberculosis (TB) is characterized by dense collections of tissue-specific and recruited macrophages, both of which abundantly express CSF1R on their outer surface. 4-Cyano-N-(5-(1-(dimethylglycyl)piperidin-4-yl)-2',3',4',5'-tetrahydro-[1,1'-biphenyl]-2-yl)-1H-imidazole-2-carboxamide (JNJ-28312141) is a reported high affinity, CSF1R-selective antagonist. We report the radiosynthesis of 4-cyano-N-(5-(1-(N-methyl-N-([

methodsNor-methyl-JNJ-28312141 precursor was radiolabeled with [

resultsRadiosynthesis of [

conclusion[

Indexed as

Positron Emission Tomography Computed TomographyTuberculosisAnimalsBiphenyl CompoundsDisease Models, AnimalImidazolesMicePositron-Emission TomographyReceptors, Granulocyte-Macrophage Colony-Stimulating FactorTomography, X-Ray ComputedbiphenylBiphenyl CompoundsCsf1r protein, mouseImidazolesReceptors, Granulocyte-Macrophage Colony-Stimulating FactorCD115CSF1RGranulomasMacrophagesM-CSFRPETTB

Identifiers

PMID35713665
PMCPMC9922090
OpenAlexW4283014505

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.