Evidence map›Paper›PMID 35713497›Full record

ArticleRheumatology (Oxford, England)2023

Validation of the parent global assessment as a health-related quality of life measure in juvenile idiopathic arthritis: results from ReACCh-Out.

Kiem Oen, Karine Toupin-April, Brian M Feldman, Roberta A Berard, Ciẚran M Duffy, Lori B Tucker, Jiahao Tian, Dax G Rumsey, Jaime Guzman, ReACCh-Out investigators

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Rheumatology (Oxford, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 1 country.

Kiem OenDepartment of Pediatrics and Child Health, University of Manitoba, Winnipeg.
Karine Toupin-AprilSchool of Rehabilitation Sciences and Department of Pediatrics, University of Ottawa, Children's Hospital of Eastern Ontario Research Institute and Institut du Savoir Montfort, Ottawa.
Brian M FeldmanDivision of Rheumatology, The Hospital for Sick Children, and Departments of Pediatrics and Medicine, and Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto.ORCID 0000-0002-7813-9665
Roberta A BerardPediatric Rheumatology, Children's Hospital, London Health Sciences Centre, London.ORCID 0000-0003-2780-0617
Ciẚran M DuffyChildren's Hospital of Eastern Ontario and Department of Pediatrics, University of Ottawa, Ottawa.
Lori B TuckerDivision of Pediatric Rheumatology, British Columbia Children's Hospital, and Department of Pediatrics, University of British Columbia, Vancouver.
Jiahao TianDepartment of Statistics and Actuarial Science, Simon Fraser University, Burnaby.
Dax G RumseyPaediatric Rheumatology, Stollery Children's Hospital and Department of Pediatrics, University of Alberta, Edmonton, Canada.
Jaime GuzmanDivision of Pediatric Rheumatology, British Columbia Children's Hospital, and Department of Pediatrics, University of British Columbia, Vancouver.ORCID 0000-0001-8977-2581
ReACCh-Out investigators
University of Ottawa · CAUniversity of British Columbia · CAUniversity of Toronto · CALondon Health Sciences Centre · CASimon Fraser University · CAUniversity of Alberta · CAUniversity of Manitoba · CA

Funding

CIHR QNT 69301
6 · The paper itself

Abstract

objectivesTo (i) validate the JIA parent global assessment (parent global) as a health-related quality of life (HRQoL) instrument; (ii) evaluate measurement properties of accepted HRQoL measures relative to those of the parent global; and (iii) assess causal pathways determining parent global scores.

methodsData from the Research in Arthritis in Canadian Children emphasizing outcomes (ReACCh-Out) cohort were used. Measurement properties were assessed in 344 patients at enrolment and 6 months later. Causal pathways were tested by structural equation modelling to understand root causes and mediators leading to parent global scores.

resultsConstruct validity was supported by Spearman correlations of 0.53-0.70 for the parent global with the Juvenile Arthritis Quality of Life Questionnaire, Quality of My Life health scale (HRQoML), Pediatric Quality of Life Inventory (PedsQL)-Parent, and Child Health Questionnaire (CHQ)-Physical. Exceptions were PedsQL-Child (0.44) and CHQ-Psychosocial (0.31). Correlations were lower (0.14-0.49) with disease activity measures (physician global assessment of disease activity, active joint count, ESR). Responsiveness of the parent global to improvement according to parent ratings (0.51) was acceptable and within the range (0.32-0.71) of that of other measures. Reliability estimates and measurement errors for all measures were unsatisfactory, likely due to the prolonged time between assessments. Causal pathways for the parent global matched those previously reported for HRQoML.

conclusionsOur results offer support for the parent global as a valid measure of HRQoL for JIA. If confirmed, existing studies using the parent global may be re-interpreted, enhancing our knowledge of HRQoL in children with JIA.

Indexed as

Arthritis, JuvenileQuality of LifeCanadaDisability EvaluationHealth StatusHumansParentsPsychometricsReproducibility of Resultshealth-related quality of lifeJIAParent global assessment

Identifiers

PMID35713497
PMCPMC9949712
OpenAlexW4283069830

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.