Evidence map›Paper›PMID 35713447›Full record

Trial reportMedicine2022

Use of ginger to control nausea and vomiting caused by chemotherapy in patients with cervical cancer undergoing treatment: An experiment.

Romeika Lorena Mendes da Silva, Tâmara Taynah Medeiros da Silva, Renata Lima Pessoa, Ayane Cristine Alves Sarmento, Kleyton Santos Medeiros, Daniele Vieira Dantas, Rodrigo Assis Neves Dantas

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07315412 (Comparative Effectiveness of Ginger-Mint and Cinnamon-Flavored Gum in Preventing Nausea and Vomiting Following Pressurized Intraperitoneal Aerosol Chemotherapy), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07315412 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Comparative Effectiveness of Ginger-Mint and Cinnamon-Flavored Gum in Preventing Nausea and Vomiting Following Pressurized Intraperitoneal Aerosol Chemotherapy

TypeinterventionalSponsorFenerbahce UniversityRan2025 to 2027Enrolled75ConditionsPostoperative Nausea and Vomiting (PONV), Peritoneal Metastases From Colorectal Cancer, Intraperitoneal ChemotherapyArmsGinger-Mint Chewing Gum, Cinnamon Chewing Gum
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Effect ofIntegrative cancer therapies
    Trial
  2. Review
  3. Review
  4. Article
  5. Organoid technology in cervical cancer research.American journal of cancer research · 2025
    Review
  6. Article
  7. GATA1 activates HSD17B6 to improve efficiency of cisplatin in lung adenocarcinoma via DNA damage.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2024
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 6 countries.

Romeika Lorena Mendes da SilvaResearch and Innovation Teaching Institute, Liga Contra o Cancer. Natal, RN, Brazil.
Tâmara Taynah Medeiros da SilvaNursing Graduate Program, Federal University of Rio Grande do Norte, Natal, Brazil.
Renata Lima PessoaHealth Sciences Postgraduate Program, Federal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil.
Ayane Cristine Alves SarmentoHealth Sciences Postgraduate Program, Federal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil.
Kleyton Santos MedeirosResearch and Innovation Teaching Institute, Liga Contra o Cancer. Natal, RN, Brazil.ORCID 0000-0002-4105-7535
Daniele Vieira DantasNursing Graduate Program, Federal University of Rio Grande do Norte, Natal, Brazil.
Rodrigo Assis Neves DantasNursing Graduate Program, Federal University of Rio Grande do Norte, Natal, Brazil.
Universidade Federal do Rio Grande do Norte · BRLiga Contra el Cancer · PE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionUterine cervix tumors have an invasive nature, with the capacity to proliferate to surrounding organs such as the vagina, bladder, and rectum, as well as the capacity for dissemination and involvement of structures distant from its place of origin. According to the International Federation of Gynecology and Obstetrics, patients with stages IB I, IB I microscopic (small dimension <4 cm) are indicated for radiotherapy or adjuvant chemoradiotherapy with cisplatin (40 mg/m2). However, cisplatin has side effects such as hematological implications (anemia, neutropenia, and thrombocytopenia), gastrointestinal disorders (nausea, vomiting, diarrhea, constipation), and fatigue. Zingiber officinale contains bioactive compounds that act on pregnancy and postoperative nausea, chemotherapy-induced nausea and vomiting, and also in the management of fatigue, myalgia, and insomnia. This study aimed to evaluate the effects of ginger on chemotherapy-induced nausea and vomiting in patients with cervical cancer undergoing treatment with cisplatin and radiotherapy. METHODS AND ANALYSES: A randomized intervention clinical and controlled trial with a triple-blind design is described, comparing the effects of institutional antiemetic therapy alone, as well as in combination with 2 different ginger concentrations. ETHICS AND DISSEMINATION: Due to the nature of the study, we obtained approval from the Division Ethics Committee of Liga Contra o Câncer. All participants signed an informed consent form prior to randomization. The results of this study will be published in peer-reviewed journals. The data collected will also be available in a public repository of data. TRIAL REGISTRATION NUMBER: This study is registered in the Brazilian Registry of Clinical Trials under number RBR-47yx6p9. This study was approved by the Division Ethics Committee of Liga Contra o Câncer under CAAE 40602320.0.0000.5293.

Indexed as

AntiemeticsAntineoplastic AgentsUterine Cervical NeoplasmsZingiber officinaleCisplatinFatigueFemaleHumansPostoperative Nausea and VomitingPregnancyVomitingAntiemeticsAntineoplastic AgentsCisplatin

Identifiers

PMID35713447
PMCPMC9276410
OpenAlexW4283066423

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.