Evidence map›Paper›PMID 35713357›Full record

ArticleMagnetic resonance in medicine2022

MR Fingerprinting with b-Tensor Encoding for Simultaneous Quantification of Relaxation and Diffusion in a Single Scan.

Maryam Afzali, Lars Mueller, Ken Sakaie, Siyuan Hu, Yong Chen, Filip Szczepankiewicz, Mark A Griswold, Derek K Jones, Dan Ma

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Article
  2. Magnetic resonance imaging.Science advances · 2026
    Review
  3. Article
  4. Review
  5. A MR Fingerprinting Development Kit for Quantitative 3D Brain Imaging.Journal of magnetic resonance imaging : JMRI · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Simultaneous liver TMagnetic resonance in medicine · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Time-resolved MR fingerprinting for TMagnetic resonance in medicine · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Maryam AfzaliLeeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.ORCID 0000-0003-3378-0878
Lars MuellerLeeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.
Ken SakaieImaging Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Siyuan HuBiomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.ORCID 0000-0003-3137-0605
Yong ChenRadiology, Case Western Reserve University, Cleveland, Ohio, USA.
Filip SzczepankiewiczClinical Sciences Lund, Lund University, Lund, Sweden.
Mark A GriswoldRadiology, Case Western Reserve University, Cleveland, Ohio, USA.ORCID 0000-0002-3011-6747
Derek K JonesCardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, UK.ORCID 0000-0003-4409-8049
Dan MaBiomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.ORCID 0000-0003-1664-9579

Funding

MR Fingerprinting for EpilepsyR01NS109439 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI Dan Ma, Zhong Irene Wang · 2019 to 2026
$4.2M
A Framework to Design 3D Quantitative Magnetic Resonance Fingerprinting (MRF) Scans and Reduce Patient AnxietyR21EB026764 · NIBIB · CASE WESTERN RESERVE UNIVERSITY · PI MA, DAN · 2018 to 2020
$641k
NIBIB NIH HHS R21 EB026764NINDS NIH HHS R01 NS109439Wellcome TrustWellcome Trust 096646/Z/11/ZWellcome Trust 104943/Z/14/ZWellcome Trust 219536/Z/19/Z
6 · The paper itself

Abstract

purposeAlthough both relaxation and diffusion imaging are sensitive to tissue microstructure, studies have reported limited sensitivity and robustness of using relaxation or conventional diffusion alone to characterize tissue microstructure. Recently, it has been shown that tensor-valued diffusion encoding and joint relaxation-diffusion quantification enable more reliable quantification of compartment-specific microstructural properties. However, scan times to acquire such data can be prohibitive. Here, we aim to simultaneously quantify relaxation and diffusion using MR fingerprinting (MRF) and b-tensor encoding in a clinically feasible time.

methodsWe developed multidimensional MRF scans (mdMRF) with linear and spherical b-tensor encoding (LTE and STE) to simultaneously quantify T1, T2, and ADC maps from a single scan. The image quality, accuracy, and scan efficiency were compared between the mdMRF using LTE and STE. Moreover, we investigated the robustness of different sequence designs to signal errors and their impact on the maps.

resultsT1 and T2 maps derived from the mdMRF scans have consistently high image quality, while ADC maps are sensitive to different sequence designs. Notably, the fast imaging steady state precession (FISP)-based mdMRF scan with peripheral pulse gating provides the best ADC maps that are free of image distortion and shading artifacts.

conclusionWe demonstrated the feasibility of quantifying T1, T2, and ADC maps simultaneously from a single mdMRF scan in around 24 s/slice. The map quality and quantitative values are consistent with the reference scans.

Indexed as

BrainMagnetic Resonance ImagingDiffusionImage Processing, Computer-AssistedPhantoms, ImagingRadionuclide Imagingb-tensor encodingdiffusion imagingmagnetic resonance fingerprintingmultidimensional MRFquantitative MRrelaxometry

Identifiers

PMID35713357
PMCPMC9420788

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.