Evidence map›Paper›PMID 35713346›Full record

ArticleAnnals of neurology2022

Risk Factors and Incidence of Epilepsy after Severe Traumatic Brain Injury.

Matthew Pease, Jorge Gonzalez-Martinez, Ava Puccio, Enyinna Nwachuku, James F Castellano, David O Okonkwo, Jonathan Elmer

Abstract read
In one paragraph

Article in Annals of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  16. Synaptic Pathology in Traumatic Brain Injury and Therapeutic Insights.International journal of molecular sciences · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Matthew PeaseDepartment of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.ORCID 0000-0001-6125-9858
Jorge Gonzalez-MartinezDepartment of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Ava PuccioDepartment of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Enyinna NwachukuDepartment of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
James F CastellanoDepartment of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
David O OkonkwoDepartment of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Jonathan ElmerDepartment of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Funding

Quantitative electroencephalography after cardiac arrestK23NS097629 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ELMER, JONATHAN · 2017 to 2021
$945k
NINDS NIH HHS K23 NS097629
6 · The paper itself

Abstract

We determined the incidence of post-traumatic epilepsy after severe traumatic brain injury. Of 392 patients surviving to discharge, cumulative incidence of post-traumatic epilepsy was 25% at 5 years and 32% at 15 years, an increase compared with historical reports. Among patients with one late seizure (>7 days post-trauma), the risk of seizure recurrence was 62% after 1 year and 82% at 10 years. Competing hazards regression identified age, decompressive hemicraniectomy, and intracranial infection as independent predictors of post-traumatic epilepsy. Patients with severe traumatic brain injury and a single late post-traumatic seizure will likely require long-term antiseizure medicines. ANN NEUROL 2022;92:663-669.

Indexed as

Brain Injuries, TraumaticEpilepsyEpilepsy, Post-TraumaticHumansIncidenceRisk FactorsSeizures

Identifiers

PMID35713346
PMCPMC9489614

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.