ArticleMolecular microbiology2022
Ino80 is required for H2A.Z eviction from hypha-specific promoters and hyphal development of Candida albicans.
Article in Molecular microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 8 citations in OpenAlex.
- Chromatin Remodeling Factor Arp8 Is Involved in the Regulation of Aflatoxin Biosynthesis and Fungal Pathogenicity ofJournal of fungi (Basel, Switzerland) · 2026Article
- PIF transcription factors-versatile plant epigenome landscapers.Frontiers in epigenetics and epigenomics · 2024Review
- Chromatin remodeling factor, INO80, inhibits PMAIP1 in renal tubular cells via exchange of histone variant H2A.Z. for H2A.Scientific reports · 2023Article
- Morphogenic plasticity: the pathogenic attribute of Candida albicans.Current genetics · 2023Review
- An essential role for the Ino80 chromatin remodeling complex in regulation of gene expression during cellular quiescence.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2023Article
- Fun30 nucleosome remodeller regulates white-to-opaque switching inActa biochimica et biophysica Sinica · 2023Article
- Ino80 is required for H2A.Z eviction from hypha-specific promoters and hyphal development of Candida albicans.Molecular microbiology · 2022Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
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Abstract
ATP-dependent chromatin remodeling complexes play important roles in many essential cellular processes, including transcription regulation, DNA replication, and repair. Evicting H2A.Z, a variant of histone H2A, from the promoter of hypha-specific genes is required for hyphal formation in Candida albicans. However, the mechanism that regulates H2A.Z removal during hyphal formation remains unknown. In this study, we demonstrated that Ino80, the core catalytic subunit of the INO80 complex, was recruited to hypha-specific promoters during hyphal induction in Arp8 dependent manner and facilitated the removal of H2A.Z. Deleting INO80 or mutating the ATPase site of Ino80 impairs the expression of hypha-specific genes (HSGs) and hyphal development. In addition, we showed that Ino80 was essential for the virulence of C. albicans during systemic infections in mice. Interestingly, Arp5, an INO80 complex-specific component, acts in concert with Ino80 during DNA damage responses but is dispensable for hyphal induction. Our findings clarified that Ino80 was critical for hyphal development, DNA damage response, and pathogenesis in C. albicans.
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