Evidence map›Paper›PMID 35713021›Full record

ArticleEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin2022

Reactive vaccination as control strategy for an outbreak of invasive meningococcal disease caused by

Cecilia Fazio, Laura Daprai, Arianna Neri, Marcello Tirani, Paola Vacca, Milena Arghittu, Luigina Ambrosio, Danilo Cereda, Maria Gramegna, Annapina Palmieri and 12 more

Open access · diamondAbstract read
In one paragraph

Article in Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 5 institutions in 1 country.

Cecilia FazioDepartment of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
Laura DapraiUnit of Microbiology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Arianna NeriDepartment of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
Marcello TiraniDirectorate General for Health, Lombardy Region, Milan, Italy.
Paola VaccaDepartment of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
Milena ArghittuLaboratory of Microbiology, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Milan, Italy.
Luigina AmbrosioDepartment of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
Danilo CeredaDirectorate General for Health, Lombardy Region, Milan, Italy.
Maria GramegnaDirectorate General for Health, Lombardy Region, Milan, Italy.
Annapina PalmieriDepartment of Cardiovascular, Endocrine-metabolic Diseases and Aging, Istituto Superiore di Sanità, Rome, Italy.
Anna CarannanteDepartment of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
Maria Rosa BertoliHealth Protection Agency of Bergamo, Bergamo, Italy.
Lucia CrottoginiDirectorate General for Health, Lombardy Region, Milan, Italy.
Giorgio GennatiHealth Protection Agency of Bergamo, Bergamo, Italy.
Eugenia QuinzHealth Protection Agency of Bergamo, Bergamo, Italy.
Livia TrezziHealth Protection Agency of Bergamo, Bergamo, Italy.
Andrea CiammaruconiScientific Departement, Army Medical Center, Rome, Italy.
Silvia FilloScientific Departement, Army Medical Center, Rome, Italy.
Antonella FortunatoScientific Departement, Army Medical Center, Rome, Italy.
Giovanni RezzaDirectorate General of Health Prevention, Ministry of Health, Rome, Italy.
Florigio ListaScientific Departement, Army Medical Center, Rome, Italy.
Paola StefanelliDepartment of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
Istituto Superiore di Sanità · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITMinistero della Salute · ITRegione LombardiaAgenzia Regionale per la Protezione Ambientale del Piemonte · IT

Funding

Wellcome Trust
6 · The paper itself

Abstract

In Italy, serogroup C meningococci of the clonal complex cc11 (MenC/cc11) have caused several outbreaks of invasive meningococcal disease (IMD) during the past 20 years. Between December 2019 and January 2020, an outbreak of six cases of IMD infected with MenC/cc11 was identified in a limited area in the northern part of Italy. All cases presented a severe clinical picture, and two of them were fatal. This report is focused on the microbiological and molecular analysis of meningococcal isolates with the aim to reconstruct the chain of transmission. It further presents the vaccination strategy adopted to control the outbreak. The phylogenetic evaluation demonstrated the close genetic proximity between the strain involved in this outbreak and a strain responsible for a larger epidemic that had occurred in 2015 and 2016 in the Tuscany Region. The rapid identification and characterisation of IMD cases and an extensive vaccination campaign contributed to the successful control of this outbreak caused by a hyperinvasive meningococcal strain.

Indexed as

Meningococcal InfectionsMeningococcal VaccinesNeisseria meningitidisDisease OutbreaksHumansItalyPhylogenySerogroupVaccinationMeningococcal Vaccinesclonal complex 11invasive meningocococcal diseaseItalyNeisseria meningitidisoutbreakserogroup C meningococcal vaccination

Identifiers

PMID35713021
PMCPMC9205164
OpenAlexW4283027788

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.