Evidence map›Paper›PMID 35712992›Full record

ArticleESC heart failure2022

Impaired renal function and mortalities in acute heart failure with different phenotypes.

Wei-Ming Huang, Hao-Chih Chang, Ching-Wei Lee, Chi-Jung Huang, Wen-Chung Yu, Hao-Min Cheng, Chao-Yu Guo, Chern-En Chiang, Chen-Huan Chen, Shih-Hsien Sung

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PubMed Full text at PMC Publisher
In one paragraph

Article in ESC heart failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Wei-Ming HuangDepartment of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Hao-Chih ChangDepartment of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Ching-Wei LeeDepartment of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Chi-Jung HuangDepartment of Medical Education, Taipei Veterans General Hospital, Taipei, Taiwan.
Wen-Chung YuDepartment of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Hao-Min ChengDepartment of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Chao-Yu GuoInstitute of Public Health, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Chern-En ChiangDepartment of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Chen-Huan ChenDepartment of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Shih-Hsien SungDepartment of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.ORCID 0000-0001-9441-1836
National Yang Ming Chiao Tung University · TWMinistry of Health and Welfare · KRTaipei Veterans General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsImpaired renal function (IRF) prevails in patients with acute heart failure. The study aimed to investigate the prevalence of on-admission IRF and its association with short-term and long-term mortalities in patients hospitalized for HF with reduced (HFrEF), mildly reduced (HFmrEF), and preserved (HFpEF) left ventricular ejection fraction (LVEF).

methodsPatients hospitalized for acute heart failure were enrolled and stratified by LVEF into three phenotypes as HFpEF (≥50%), HFmrEF (40-49%), and HFrEF (<40%). IRF was defined as an estimated glomerular filtration rate of ≤60 mL/min/1.73m

resultsOf 2613 patients enrolled, 673 (25.7%) had HFrEF, 367 (14.0%) had HFmrEF, and 1573 (60.1%) had HFpEF, whereas IRF was prevalent among 63.7, 68.6, and 67.5% of them, respectively. IRF significantly correlated with higher long-term mortality in each phenotype of HF. However, IRF was associated with 90-day and 1-year mortality in subjects with HFrEF and HFmrEF, but not HFpEF. After accounting for age, gender, hypertension, diabetes, coronary artery disease, atrial fibrillation, stroke, serum sodium, de novo heart failure, date of enrolment, and systolic blood pressure <90 mmHg or use of inotropic agents, IRF remained related to 5-year mortality in patients with HFrEF (hazard ratio and 95% confidence interval: 1.346, 1.034-1.751), HFmrEF (2.210, 1.435-3.404), and HFpEF (1.493, 1.237-1.801).

conclusionsOn-admission IRF was independently predictive of long-term mortality in patients hospitalized for HF, irrespective of HF phenotypes. Furthermore, IRF was also associated with short-term mortality in HFrEF and HFmrEF, but not in HFpEF.

Indexed as

Heart FailureHumansKidneyPhenotypePrognosisStroke VolumeVentricular Function, LeftAcute heart failureAll-cause mortalityImpaired renal functionLeft ventricular ejection fraction

Identifiers

PMID35712992
PMCPMC9715785
OpenAlexW4283020091

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.