Evidence map›Paper›PMID 35712882›Full record

ArticleMolecular pain2022

Armadillo regulates nociceptive sensitivity in the absence of injury.

Christine Hale, Julie Moulton, Yvonne Otis, Geoffrey Ganter

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pain, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. The nociceptor primary cilium.Brain : a journal of neurology · 2026
    Review
  2. The Nociceptor Primary Cilium Contributes to Mechanical Nociceptive Threshold and Inflammatory and Neuropathic Pain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Christine HaleGraduate School of Biomedical Science and Engineering, University of Maine, Orono, ME, USA.ORCID 0000-0002-3600-4607
Julie MoultonSchool of Biological Sciences, College of Arts and Sciences, University of New England, Biddeford, ME, USA.ORCID 0000-0001-8810-715X
Yvonne OtisSchool of Biological Sciences, College of Arts and Sciences, University of New England, Biddeford, ME, USA.ORCID 0000-0003-3457-4478
Geoffrey GanterGraduate School of Biomedical Science and Engineering, University of Maine, Orono, ME, USA.ORCID 0000-0001-7726-2111
University of New England · US

Funding

Tissue resident macrophages in sensory ganglia: function and impact on nociceptionP20GM103643 · NIGMS · UNIVERSITY OF NEW ENGLAND · PI MENG, IAN D · 2012 to 2021
$20.9M
Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Drosophila Transgenic RNAi Resource ProjectR01GM084947 · NIGMS · HARVARD MEDICAL SCHOOL · PI PERRIMON, NORBERT · 2008 to 2019
$9.8M
Characterization of the signaling pathways that produce nociceptor sensitization in DrosophilaR15NS095195 · NINDS · UNIVERSITY OF NEW ENGLAND · PI GANTER, GEOFFREY · 2015 to 2020
$869k
NIGMS NIH HHS P20 GM103643NIGMS NIH HHS R01 GM084947NIH HHS P40 OD018537NINDS NIH HHS R15 NS095195
6 · The paper itself

Abstract

Abnormal pain has recently been estimated to affect ∼50 million adults each year within the United States. With many treatment options for abnormal pain, such as opioid analgesics, carrying numerous deleterious side effects, research into safer and more effective treatment options is crucial. To help elucidate the mechanisms controlling nociceptive sensitivity, the

Indexed as

Armadillo Domain Proteinsbeta CateninDrosophila ProteinsNociceptionTranscription FactorsAnalgesics, OpioidAnimalsDrosophila melanogasterPainAnalgesics, OpioidArmadillo Domain ProteinsARM protein, Drosophilabeta CateninDrosophila ProteinsTranscription Factorsactivatoradherens, cateninhypersensitivitynociceptorpainRNAiwgwnt

Identifiers

PMID35712882
PMCPMC9500252
OpenAlexW4283030849

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.