ArticleJournal of clinical laboratory analysis2022
Prevalence and correlative factors of hyperhomocysteinemia in elderly patients with femoral neck fracture: A cross-sectional study.
Article in Journal of clinical laboratory analysis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 3 citations in OpenAlex.
- Association of Triglyceride-Glucose Index with the Risk of Hyperhomocysteinemia Among Chinese Male Bus Drivers: A Longitudinal Study.International journal of general medicine · 2023Article
- Prevalence and correlative factors of hyperhomocysteinemia in elderly patients with femoral neck fracture: A cross-sectional study.Journal of clinical laboratory analysis · 2022Article
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4 authors at 1 institution in 1 country.
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Abstract
aimsThe occurrence of hyperhomocysteinemia (HHcy) in elderly patients with femoral neck fracture (FNF) draws little attention from surgeons preoperatively. The aim of our study was to determine the prevalence and correlative factors of HHcy in elderly patients (≥65 years) with FNF prior to surgery.
methodsWe retrospectively investigated 286 elderly FNF patients aged 65-98 years admitted to our institution from September 2020 to September 2021. Categorical variables were compared using the Chi-squared test, and continuous variables were compared using the Mann-Whitney U test. Univariable and multivariable logistic regression were used to determine the associations of variables with the odds of HHcy.
resultsAmong the 286 elderly FNF patients, the prevalence of HHcy was 30.77% and the mean Hcy level was 14.52 ± 10.49 μmol/L. The mean Hcy level and the prevalence of HHcy in male patients were significantly higher than that in female patients (16.41 ± 9.58 μmol/L vs. 14.00 ± 10.69 μmol/L, p = 0.002; 43.55% vs. 27.23%, p = 0.014). Multivariate analysis indicated that being male patient (OR 2.187, 95% CI 1.187-4.028, p = 0.012), hypertension (OR 1.993, 95% CI 1.141-3.479, p = 0.015), and low HDL-C (OR 2.979, 95% CI 1.353-6.558, p = 0.007) were significant correlative factors of HHcy among elderly FNF patients.
conclusionsThis study found a high prevalence of HHcy in elderly FNF patients, with being male patient, hypertension, and low levels of HDL-C as the significant correlative factors after adjusting for age and other covariables. However, further large-scale studies in wider regions are warranted to confirm these findings.
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