Evidence map›Paper›PMID 35712774›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2022

Chemical Factory-Guaranteed Enhanced Chemodynamic Therapy for Orthotopic Liver Cancer.

Zhongmin Tang, Shiman Wu, Peiran Zhao, Han Wang, Dalong Ni, Huiyan Li, Xingwu Jiang, Yelin Wu, Yun Meng, Zhenwei Yao and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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  17. Chemical Factory-Guaranteed Enhanced Chemodynamic Therapy for Orthotopic Liver Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zhongmin TangTongji University Cancer Center, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, P. R. China.
Shiman WuDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040, P. R. China.
Peiran ZhaoDepartment of Materials Science and State Key Laboratory of Molecular Engineering of Polymers, Fudan University, 220 Handan Road, Shanghai, 200438, P. R. China.
Han WangRuijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200240, P. R. China.
Dalong NiRuijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200240, P. R. China.
Huiyan LiDepartment of Materials Science and State Key Laboratory of Molecular Engineering of Polymers, Fudan University, 220 Handan Road, Shanghai, 200438, P. R. China.
Xingwu JiangDepartment of Materials Science and State Key Laboratory of Molecular Engineering of Polymers, Fudan University, 220 Handan Road, Shanghai, 200438, P. R. China.
Yelin WuTongji University Cancer Center, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, P. R. China.
Yun MengTongji University Cancer Center, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, P. R. China.
Zhenwei YaoDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040, P. R. China.
Weibo CaiDepartments of Radiology, Medical Physics, Materials Science & Engineering, Pharmaceutical Sciences, University of Wisconsin - Madison, Madison, WI, 53705, USA.
Wenbo BuTongji University Cancer Center, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, P. R. China.ORCID 0000-0001-6664-3453

Funding

Key Project of Shanghai Science and Technology Commission 19JC1412000National Funds for Distinguished Young Scientists 51725202National Natural Science Foundation of China 51872094National Natural Science Foundation of China 81671732
6 · The paper itself

Abstract

In the field of nanomedicine, there is a tendency of matching designed nanomaterials with a suitable type of orthotopic cancer model, not just a casual subcutaneous one. Under this condition, knowing the specific features of the chosen cancer model is the priority, then introducing a proper therapy strategy using designed nanomaterials. Here, the Fenton chemistry is combined with zinc peroxide nanoparticles in the treatment of orthotopic liver cancer which has a "chemical factory" including that liver is the main place for iron storage, metabolism, and also the main metabolic sites for the majority of ingested substances, guaranteeing customized and enhanced chemodynamic therapy and normal liver cells protection as well. The good results in vitro and in vivo can set an inspiring example for exploring and utilizing suitable nanomaterials in corresponding cancer models, ensuring well-fitness of nanomaterials for disease and satisfactory therapeutic effect.

Indexed as

Liver NeoplasmsNanoparticlesNanostructuresHumansNanomedicinePhototherapychemical factoryFentonliver cancermetabolismzinc peroxide

Identifiers

PMID35712774
PMCPMC9376848

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.