Evidence map›Paper›PMID 35712524›Full record

ArticleJournal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America2022

Fast Univariate Inference for Longitudinal Functional Models.

Erjia Cui, Andrew Leroux, Ekaterina Smirnova, Ciprian M Crainiceanu

Open access · greenAbstract read
In one paragraph

Article in Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 49 citations in OpenAlex.

  1. Trial
  2. ABEL: an active-learning behavior estimation and labeling platform.bioRxiv : the preprint server for biology · 2026
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  10. Functional quantile principal component analysis.Biostatistics (Oxford, England) · 2025
    Article
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  15. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Erjia CuiDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, USA.
Andrew LerouxDepartment of Biostatistics and Informatics, University of Colorado, USA.
Ekaterina SmirnovaDepartment of Biostatistics, Virginia Commonwealth University, USA.
Ciprian M CrainiceanuDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, USA.
Johns Hopkins University · USUniversity of Colorado Boulder · USVirginia Commonwealth University · US

Funding

EPIDEMIOLOGY AND BIOSTATISTICS OF AGINGT32AG000247 · NIA · JOHNS HOPKINS UNIVERSITY · PI Karen J. Bandeen-Roche · 1996 to 2026
$13.2M
Statistical Methods for Multilevel Multivariate Functional StudiesR01NS060910 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Ciprian M Crainiceanu · 2009 to 2026
$8.3M
Statistical methods to improve reproducibility and reduce technical variability in heterogeneous multimodal neuroimaging studies of Alzheimer’s DiseaseR01AG063752 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TUDORASCU, DANA L · 2019 to 2023
$3.0M
NIA NIH HHS R01 AG063752NIA NIH HHS T32 AG000247NINDS NIH HHS R01 NS060910
6 · The paper itself

Abstract

We propose fast univariate inferential approaches for longitudinal Gaussian and non-Gaussian functional data. The approach consists of three steps: (1) fit massively univariate pointwise mixed effects models; (2) apply any smoother along the functional domain; and (3) obtain joint confidence bands using analytic approaches for Gaussian data or a bootstrap of study participants for non-Gaussian data. Methods are motivated by two applications: (1) Diffusion Tensor Imaging (DTI) measured at multiple visits along the corpus callosum of multiple sclerosis (MS) patients; and (2) physical activity data measured by body-worn accelerometers for multiple days. An extensive simulation study indicates that model fitting and inference are accurate and much faster than existing approaches. Moreover, the proposed approach was the only one that was computationally feasible for the physical activity data application. Methods are accompanied by R software, though the method is "read-and-use", as it can be implemented by any analyst who is familiar with mixed effects model software.

Indexed as

DTIlongitudinal functional datamixed modelwearable devices

Identifiers

PMID35712524
PMCPMC9197085
OpenAlexW3178302756

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.