Evidence map›Paper›PMID 35712500›Full record

ArticleFrontiers in oncology2022

Stable Isotope Tracing Uncovers Reduced γ/β-ATP Turnover and Metabolic Flux Through Mitochondrial-Linked Phosphotransfer Circuits in Aggressive Breast Cancer Cells.

Aleksandr Klepinin, Sten Miller, Indrek Reile, Marju Puurand, Egle Rebane-Klemm, Ljudmila Klepinina, Heiki Vija, Song Zhang, Andre Terzic, Petras Dzeja and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Use of Nuclear Magnetic Resonance (NMR) to Study Cancer Metabolism.Advances in experimental medicine and biology · 2026
    Review
  3. Article
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Aleksandr KlepininLaboratory of Chemical Biology, National Institute of Chemical Physics and Biophysics, Tallinn, Estonia.
Sten MillerLaboratory of Chemical Biology, National Institute of Chemical Physics and Biophysics, Tallinn, Estonia.
Indrek ReileLaboratory of Chemical Physics, National Institute of Chemical Physics and Biophysics, Tallinn, Estonia.
Marju PuurandLaboratory of Chemical Biology, National Institute of Chemical Physics and Biophysics, Tallinn, Estonia.
Egle Rebane-KlemmLaboratory of Chemical Biology, National Institute of Chemical Physics and Biophysics, Tallinn, Estonia.
Ljudmila KlepininaLaboratory of Chemical Biology, National Institute of Chemical Physics and Biophysics, Tallinn, Estonia.
Heiki VijaLaboratory of Environmental Toxicology, National Institute of Chemical Physics and Biophysics, Tallinn, Estonia.
Song ZhangDepartment of Cardiovascular Medicine and Center for Regenerative Medicine, Mayo Clinic, Rochester, MN, United States.
Andre TerzicDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, United States.
Petras DzejaDepartment of Cardiovascular Medicine and Center for Regenerative Medicine, Mayo Clinic, Rochester, MN, United States.
Tuuli KaambreLaboratory of Chemical Biology, National Institute of Chemical Physics and Biophysics, Tallinn, Estonia.
National Institute of Chemical Physics and Biophysics · EEMayo Clinic in Arizona · USTallinn University of Technology · EEMayo Clinic · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Changes in dynamics of ATP γ- and β-phosphoryl turnover and metabolic flux through phosphotransfer pathways in cancer cells are still unknown. Using

Indexed as

18 O stable isotope labeling technologyadenylate kinasecreatine kinaseglycolysisoxidative phosphorylationphosphotransfer networktriple-negative breast cancerγ-and β-ATP phosphoryl turnover

Identifiers

PMID35712500
PMCPMC9194814
OpenAlexW4281711886

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.