Evidence map›Paper›PMID 35711853›Full record

ArticleMedComm2022

Yi-Yang Gao, Rui-Qin Yang, Kang-Liang Lou, Yong-Ying Dang, Yuan-Yuan Dong, Yue-Yang He, Wen-He Huang, Min Chen, Guo-Jun Zhang

Open access · goldAbstract read
In one paragraph

Article in MedComm, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. MedComm · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

Yi-Yang GaoDepartment of Breast and Thyroid Surgery Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University Xiamen China.
Rui-Qin YangDepartment of Breast and Thyroid Surgery Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University Xiamen China.
Kang-Liang LouDepartment of Breast and Thyroid Surgery Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University Xiamen China.
Yong-Ying DangDepartment of Breast and Thyroid Surgery Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University Xiamen China.
Yuan-Yuan DongDepartment of Breast and Thyroid Surgery Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University Xiamen China.
Yue-Yang HeDepartment of Breast and Thyroid Surgery Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University Xiamen China.
Wen-He HuangDepartment of Breast and Thyroid Surgery Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University Xiamen China.
Min ChenXiamen Key Laboratory of Endocrine-Related Cancer Precision Medicine Xiang'an Hospital of Xiamen University, Xiamen University Xiamen China.
Guo-Jun ZhangDepartment of Breast and Thyroid Surgery Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University Xiamen China.ORCID https://orcid.org/0000-0001-5182-5887
Xiamen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The CDK4/6-Rb axis is a crucial target of cancer therapy and several selective inhibitors of it have been approved for clinical application. However, current therapeutic efficacy evaluation mostly relies on anatomical imaging, which cannot directly reflect changes in drug targets, leading to a delay in the selection of optimal treatment. In this study, we constructed a novel fluorescent probe, CPP30-Lipo/CDKACT4, for real-time monitoring of CDK4 activity and the therapeutic efficacy of its inhibitor in HR

Indexed as

breast cancerCDK4 inhibitorsfluorescence imagingkinase activitytherapeutic evaluation

Identifiers

PMID35711853
PMCPMC9187519
OpenAlexW4281755128

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.