Evidence map›Paper›PMID 35711790›Full record

ArticleFrontiers in veterinary science2022

Enhanced Healing Activity of Manuka Honey and Nitrofurazone Composite in Full-Thickness Burn Wounds in the Rabbit Model.

Muhammad Fakhar-E-Alam Kulyar, Khurram Ashfaq, Amjad Islam Aqib, Kun Duan, Muhammad Asif, Zeeshan Ahmad Bhutta, Muhammad Shoaib, Samina Shabbir, Shah Nawaz, Muhammad Aamir Naseer and 7 more

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In one paragraph

Article in Frontiers in veterinary science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 9 institutions in 3 countries.

Muhammad Fakhar-E-Alam KulyarInstitute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Khurram AshfaqDepartment of Clinical Medicine and Surgery, University of Agriculture, Faisalabad, Pakistan.
Amjad Islam AqibDepartment of Medicine, Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan.
Kun DuanChina Tobacco Henan Industrial Co. Ltd., Zhengzhou, China.
Muhammad AsifDepartment of Surgery, University of Veterinary and Animal Sciences, Lahore, Pakistan.
Zeeshan Ahmad BhuttaLaboratory of Biochemistry and Immunology, College of Veterinary Medicine, Chungbuk National University, Cheongju, South Korea.
Muhammad ShoaibKey Laboratory of New Animal Drug Project, Gansu Province, Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of Chinese Academy of Agricultural Sciences, Lanzhou, China.
Samina ShabbirKey Laboratory of Development and Application of Rural Renewable Energy, Ministry of Agriculture and Rural Affairs, Biogas Institute of Ministry of Agriculture and Rural Affairs, Chengdu, China.
Shah NawazDepartment of Pathology, University of Agriculture, Faisalabad, Pakistan.
Muhammad Aamir NaseerDepartment of Clinical Medicine and Surgery, University of Agriculture, Faisalabad, Pakistan.
Iqra SarwarDepartment of Clinical Medicine and Surgery, University of Agriculture, Faisalabad, Pakistan.
Muhammad AkhtarCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Ayesha Safdar ChaudhryDepartment of Surgery, University of Veterinary and Animal Sciences, Lahore, Pakistan.
Riaz HussainDepartment of Pathology, Faculty of Veterinary Sciences, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.
Hafiz Iftikhar HussainDepartment of Pathology, Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan.
Yi WuInstitute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Kun LiInstitute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
University of Agriculture Faisalabad · PKUniversity of Veterinary and Animal Sciences · PKHuazhong Agricultural University · CNNanjing Agricultural University · CNChina Tobacco · CNChungbuk National University · KRIslamia University of Bahawalpur · PKLanzhou Institute of Husbandry and Pharmaceutical Sciences · CNMinistry of Agriculture and Rural Affairs · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Burns cause many significant changes in metabolism and inflammatory reactions, leading to poor regeneration in animals and humans. A list of medicines to treat burns is available in the market. But due to the high cost of these medicines, these are unaffordable, especially for farmers of middle-class families of Africa and Asia. Therefore, a low-cost complementary treatment has always been a topic of many researchers, and there is a dire need of time for the welfare of animals to save them. The current study was planned to scrutinize the therapeutic effects of Manuka honey and Nitrofurazone ointments on full-thickness burn wounds in the rabbit model. The healing efficacy was performed through wound contraction rate, hematological analysis, the thickness of dermis and epidermis, and collagen content percentage. Histopathology was performed after taking biopsy samples at the end of the research. Based on statistical analysis using wound healing time (days, D), the combination (MO + NT) resulted in a shorter period (27 D ± 1) than the average healing time of controlled (36 ± 2), Manuka ointment (31.33 D ± 1.52), and Nitrofurazone ointment (32 ± 1). A significant decrease in the count of red blood cell (RBC), mean corpuscular volume (MCV), and mean corpuscular hemoglobin (MCH) in all treatments was noticed mainly in MO + NT. Furthermore, burns induced a significant difference (

Indexed as

burnshoneyManukanatural remediesNitrofurazone

Identifiers

PMID35711790
PMCPMC9196035
OpenAlexW4281290259

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.