Evidence map›Paper›PMID 35711641›Full record

ArticleFrontiers in bioengineering and biotechnology2022

Layered Double Hydroxides-Loaded Sorafenib Inhibit Hepatic Stellate Cells Proliferation and Activation

Wei Peng, Shiwen Zhang, Wei Zhou, Xinchen Zhao, Kexue Wang, Chengxu Yue, Xinyu Wei, Siyan Pang, Wei Dong, Sulian Chen and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Wei PengAnhui Province Key Laboratory of Translational Cancer Research, Department of Biotechnology, Bengbu Medical College, Anhui, China.
Shiwen ZhangAnhui Province Key Laboratory of Translational Cancer Research, Department of Biotechnology, Bengbu Medical College, Anhui, China.
Wei ZhouAnhui Province Key Laboratory of Translational Cancer Research, Department of Biotechnology, Bengbu Medical College, Anhui, China.
Xinchen ZhaoAnhui Province Key Laboratory of Translational Cancer Research, Department of Biotechnology, Bengbu Medical College, Anhui, China.
Kexue WangAnhui Province Key Laboratory of Translational Cancer Research, Department of Biotechnology, Bengbu Medical College, Anhui, China.
Chengxu YueDepartment of Biochemistry, School of Laboratory Medicine, Bengbu Medical College, Anhui, China.
Xinyu WeiDepartment of Biochemistry, School of Laboratory Medicine, Bengbu Medical College, Anhui, China.
Siyan PangAnhui Province Key Laboratory of Translational Cancer Research, Department of Biotechnology, Bengbu Medical College, Anhui, China.
Wei DongThe Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China.
Sulian ChenDepartment of Biochemistry, School of Laboratory Medicine, Bengbu Medical College, Anhui, China.
Changjie ChenDepartment of Biochemistry, School of Laboratory Medicine, Bengbu Medical College, Anhui, China.
Qingling YangDepartment of Biochemistry, School of Laboratory Medicine, Bengbu Medical College, Anhui, China.
Wenrui WangAnhui Province Key Laboratory of Translational Cancer Research, Department of Biotechnology, Bengbu Medical College, Anhui, China.
Bengbu Medical College · CNSecond Military Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A core feature of liver fibrosis is the activation of hepatic stellate cells (HSCs), which are transformed into myofibroblasts and lead to the accumulation of extracellular matrix (ECM) proteins. In this study, we combined

Indexed as

hepatic stellate cellslayered double hydroxidesliver fibrosissorafenibTGF-β1/Smad

Identifiers

PMID35711641
PMCPMC9196193
OpenAlexW4281913147

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.