Evidence map›Paper›PMID 35711622›Full record

ArticleDesigned monomers and polymers2022

Development and characterization of niosomal gel of fusidic acid: in-vitro and ex-vivo approaches.

Muhammad Khurram Waqas, Haleema Sadia, Muhammad Imran Khan, Muhammad Ovais Omer, Muhammad Irfan Siddique, Shaista Qamar, Muhammad Zaman, Muhammad Hammad Butt, Mian Waqar Mustafa, Naeem Rasool

Abstract read
In one paragraph

Article in Designed monomers and polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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  13. Development andBioMed research international · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Muhammad Khurram WaqasInstitute of Pharmaceutical Sciences, University of Veterinary and Animal Sciences, Lahore, Pakistan.
Haleema SadiaInstitute of Pharmaceutical Sciences, University of Veterinary and Animal Sciences, Lahore, Pakistan.
Muhammad Imran KhanRiphah Institute of Pharmaceutical Sciences, Riphah University Lahore Campus, Pakistan.
Muhammad Ovais OmerDepartment of Pharmacology and Toxicology, University of Veterinary and Animal Sciences Lahore, Pakistan.
Muhammad Irfan SiddiqueInstitute of Pharmaceutical Sciences, University of Veterinary and Animal Sciences, Lahore, Pakistan.
Shaista QamarInstitute of Pharmaceutical Sciences, University of Veterinary and Animal Sciences, Lahore, Pakistan.
Muhammad ZamanFaculty of Pharmacy, University of Central Punjab, Lahore, Pakistan.
Muhammad Hammad ButtFaculty of Pharmacy, University of Central Punjab, Lahore, Pakistan.
Mian Waqar MustafaDepartment of Pharmacy, Forman Christian College University, Lahore, Pakistan.
Naeem RasoolDepartment of Pharmacology and Toxicology, University of Veterinary and Animal Sciences Lahore, Pakistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Niosomes are multilamellar vesicles that efficiently deliver active substance into skin systemic circulation or skin layers. They are used in topical drug delivery system to enhance the skin permeation of active substance. So, the prime objective of this study was to develop a niosomal gel of fusidic acid to increase its skin permeation. Different formulations of niosomes of fusidic acid were designed by varying the cholesterol to surfactant ratio. Formulations containing fusidic acid, cholesterol, dihexadecyl pyridinium chloride, Span 60, or Tween 60 were prepared by thin film hydration method in rotary evaporator. The thin film formed in rotary flask was hydrated by phosphate buffer saline of pH 7.2. The niosomes formed were characterized through entrapment efficiency, size, polydispersity index (PDI), and zeta potential. The S3 formulation containing span 60 showed the highest entrapment efficiency (EE) of niosomes, so it was incorporated into Carbopol gel. Determination of pH, spreadability, rheological, and

Indexed as

Carbopol gelFusidic acidniosomespermeationtopical

Identifiers

PMID35711622
PMCPMC9196814

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.